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Literature summary extracted from

  • Senger, M.R.; Rosemberg, D.B.; Seibt, K.J.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
    Influence of mercury chloride on adenosine deaminase activity and gene expression in zebrafish (Danio rerio) brain (2010), Neurotoxicology, 31, 291-296.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 HgCl2 inhibition of ADA activity is observed in the soluble fraction at 0.005-0.25 mM HgCl2 (84.6-92.6% respectively), whereas inhibition occurs at 0.005-0.25 mM in membrane fractions (20.9-26% respectively). The inhibition is partially or fully abolished by 0.5 mM dithiothreitol or EDTA Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.4.4 membrane
-
 Danio rerio 16020
-
3.5.4.4 soluble
-
 Danio rerio
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.4 additional information there are no significant changes in ADA activity in the presence of cadmium acetate, potassium dichromate, lead acetate, zinc chloride, copper sulfate, cobalt chloride, and manganese chloride Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 brain
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
 Danio rerio inosine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.4 ADA
-
 Danio rerio

Expression

EC Number Organism Comment Expression
3.5.4.4 Danio rerio HgCl2 does not alter ADA gene expression additional information