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Literature summary extracted from

  • Shah, P.P.; Wang, T.; Kaletsky, R.L.; Myers, M.; Puvis, J.E.; Jing, H.; Huryn, D.M.; Greenbaum, D.C.; Smith, A.B.; Bates, P.; Diamond, S.L.
    A small molecule oxocarbazate inhibitor of human cathepsin L blocks SARS and Ebola pseudotype virus infection into HEK 293T cells (2010), Mol. Pharmacol., 78, 319-324.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 benzyloxycarbonyl-Phe-Tyr-(tert-butyl)-diazomethylketone
-
 Homo sapiens
3.4.22.15 CID 16725315 2% inhibition at 0.025 mM Homo sapiens
3.4.22.15 CID 23631927 38% inhibition at 0.025 mM, sub-nanomolar slow-binding, reversible inhibitor of human cathepsin L with cathepsin L/B selectivity of above 700fold that blocks SARS-CoV and Ebola pseudotype virus entry in human cells Homo sapiens
3.4.22.15 MDL28170
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 HEK-293T cell
-
 Homo sapiens
-
3.4.22.15 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.15 CatL
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.15 0.0000069
-
 pH and temperature not specified in the publication Homo sapiens CID 23631927
3.4.22.15 0.000056
-
 pH and temperature not specified in the publication Homo sapiens CID 16725315