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Literature summary extracted from

  • Garcia, D.G.; Amorim, L.M.; de Castro Faria, M.V.; Freire, A.S.; Santelli, R.E.; Da Fonseca, C.O.; Quirico-Santos, T.; Burth, P.
    The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor (2010), Mol. Cell. Biochem., 345, 29-34.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 Ouabain
-
 Cavia porcellus
7.2.2.13 Ouabain
-
 Homo sapiens
7.2.2.13 perillyl alcohol a monoterpene, inhibits Na/K-ATPase, non-competitive inhibition for Na+ and K+ and an uncompetitive inhibition for ATP in brain and kidney Cavia porcellus
7.2.2.13 perillyl alcohol a monoterpene, inhibits Na/K-ATPase showing a noncompetitive inhibition profile to Na+ and K+ and an uncompetitive inhibition towards ATP. The generated electrochemical gradient is essential for a number of other cellular functions Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.13 plasma membrane
-
 Cavia porcellus 5886
-
7.2.2.13 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out Cavia porcellus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?
7.2.2.13 ATP + H2O + Na+/in + K+/out Homo sapiens
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Cavia porcellus
-
-
-
7.2.2.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.13 native enzyme partially from brain and kidney Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 A-172 cell glioblastoma cells, A172 cells overexpress Na/K-ATPase alpha1 isoform in the caveolar structure Homo sapiens
-
7.2.2.13 brain
-
 Cavia porcellus
-
7.2.2.13 kidney
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Cavia porcellus ADP + phosphate + Na+/out + K+/in
-
 ?
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Homo sapiens ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na/K-ATPase
-
 Cavia porcellus
7.2.2.13 Na/K-ATPase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.13 37
-
 assay at Cavia porcellus
7.2.2.13 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.13 7.4
-
 assay at Cavia porcellus
7.2.2.13 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.2.2.13 additional information
-
 additional information inhibition kinetics, overview Cavia porcellus
7.2.2.13 additional information
-
 additional information inhibition kinetics, overview Homo sapiens
7.2.2.13 1.5
-
 perillyl alcohol pH 7.4, 37°C, Na/K-ATPase-enriched A-127 cell extract Homo sapiens

General Information

EC Number General Information Comment Organism
7.2.2.13 physiological function Na/K-ATPase is a plasma membrane protein complex transferring the stored energy of ATP to the active transport of Na+ and K+ ions across the cell membrane. Na/K-ATPase alpha1 isoform modulates signaling mechanisms leading to apoptosis, cell migration, and cell proliferation Homo sapiens
7.2.2.13 physiological function Na/K-ATPase is a plasma membrane protein complex transferring the stored energy of ATP to the active transport of Na+ and K+ ions across the cell membrane. The generated electrochemical gradient is essential for a number of other cellular functions Cavia porcellus