EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | acylfulvene | reversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 1.0 or 1.25 mM acylfulvene is reduced by 30% in the presence of NDPH | Saccharomyces cerevisiae | |
1.8.1.7 | carmustine | i.e. 1,3-bis(2-chloroethyl)-1-nitroso-urea, irreversible inhibitor, complete inhibition at 0.625 mM | Saccharomyces cerevisiae | |
1.8.1.7 | hydroxymethylacylfulvene | irreversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 0.625 or 1.25 mM hydroxymethylacylfulvene is reduced by 45% in the presence of NDPH | Saccharomyces cerevisiae | |
1.8.1.7 | illudin S | - |
Saccharomyces cerevisiae | |
1.8.1.7 | additional information | up to 2 mM, illudin S does not inhibit glutathione reductase activity | Saccharomyces cerevisiae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.7 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | glutathione disulfide + NADPH + H+ | - |
Saccharomyces cerevisiae | glutathione + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.7 | EC 1.6.4.2 | formerly | Saccharomyces cerevisiae |
1.8.1.7 | glutathione reductase | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | FAD | - |
Saccharomyces cerevisiae | |
1.8.1.7 | NADPH | - |
Saccharomyces cerevisiae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.7 | 0.18 | - |
hydroxymethylacylfulvene | at 25°C, pH not specified in the publication | Saccharomyces cerevisiae |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.8.1.7 | 0.071 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | carmustine | |
1.8.1.7 | 0.216 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | hydroxymethylacylfulvene | |
1.8.1.7 | 0.871 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | acylfulvene |