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Literature summary extracted from

  • Rigobello, M.P.; Bindoli, A.
    Mitochondrial thioredoxin reductase purification, inhibitor studies, and role in cell signaling (2010), Methods Enzymol., 474, 109-122.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 54000
-
about 54000 Da, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9 ammonium sulfate precipitation, DEAE-Sephacel gel filtration, 2',5'-ADP-Sepharose 4B affinity chromatography, and omega-aminohexyl-Sepharose 4B column chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 brain
-
Rattus norvegicus
-
1.8.1.9 heart
-
Rattus norvegicus
-
1.8.1.9 kidney
-
Rattus norvegicus
-
1.8.1.9 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
1.8.1.9 alloxan + NADPH + H+
-
Rattus norvegicus ? + NADP+
-
?
1.8.1.9 selenite + NADPH + H+
-
Rattus norvegicus ? + NADP+
-
?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
Rattus norvegicus
1.8.1.9 TrxR2 also called TR3 or TRbeta Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
Rattus norvegicus
1.8.1.9 NADPH
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.8.1.9 malfunction inhibition of mitochondrial thioredoxin reductase leads to oxidation of downstream enzymes such as thioredoxin and peroxiredoxin Rattus norvegicus