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Literature summary extracted from

  • Zhao, B.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
    Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid (2010), J. Steroid Biochem. Mol. Biol., 118, 13-17.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 Perfluorooctanoic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.51 0.00067
-
 pregnenolone pH and temperature not specified in the publication Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 4-androsten-3,17-dione + NADPH + H+
-
 Rattus norvegicus testosterone + NADP+
-
 ?
1.1.1.51 pregnenolone + NADP+
-
 Rattus norvegicus progesterone + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus
1.1.1.51 3beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.51 0.0153
-
 Perfluorooctanoic acid testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication Rattus norvegicus
1.1.1.51 0.0213
-
 Perfluorooctanoic acid testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase Rattus norvegicus
1.1.1.51 0.0586
-
 Perfluorooctanoic acid intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase Rattus norvegicus
1.1.1.51 0.181
-
 Perfluorooctanoic acid intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.51 0.0177
-
 testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication Rattus norvegicus Perfluorooctanoic acid
1.1.1.51 0.0532
-
 testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase Rattus norvegicus Perfluorooctanoic acid
1.1.1.51 0.146
-
 intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase Rattus norvegicus Perfluorooctanoic acid
1.1.1.51 0.194
-
 intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication Rattus norvegicus Perfluorooctanoic acid