Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, L.; Wilson, D.J.; Xu, Y.; Aldrich, C.C.; Felczak, K.; Sham, Y.Y.; Pankiewicz, K.W.
    Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis (2010), J. Med. Chem., 53, 4768-4778.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.205 expression in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.205 modeling of complex with inhibitor 9-(5-O-[hydroxy[([hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl]oxy)methyl]phosphoryl]-b-L-ribofuranosyl)-9H-purin-6-amine Mycobacterium tuberculosis
1.1.1.205 modeling of complex with inhibitor 9-(5-O-[hydroxy[([hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl]oxy)methyl]phosphoryl]-b-L-ribofuranosyl)-9H-purin-6-amine Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 6-((E)-4-(((1-(50-deoxy-adenosin-50-yl)-1H-1,2,3-triazol-4-yl)-methyl)amino)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
-
 Homo sapiens
1.1.1.205 6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
-
 Homo sapiens
1.1.1.205 6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one uncompetitive versus IMP Mycobacterium tuberculosis
1.1.1.205 9-(5-O-[hydroxy[([hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl]oxy)methyl]phosphoryl]-beta-L-ribofuranosyl)-9H-purin-6-amine homology modeling; homology modeling Homo sapiens
1.1.1.205 NAD+
-
 Homo sapiens
1.1.1.205 NAD+
-
 Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.205 0.078
-
 inosine 5'-phosphate pH 8.0, 25°C Mycobacterium tuberculosis
1.1.1.205 1.005
-
 NAD+ pH 8.0, 25°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Homo sapiens P12268 IMPDH2
-
1.1.1.205 Homo sapiens P20839 IMPDH1
-
1.1.1.205 Mycobacterium tuberculosis
-
-
-
1.1.1.205 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+
-
 Mycobacterium tuberculosis xanthosine 5'-phosphate + NADH + H+
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+
-
 Homo sapiens xanthosine 5'-phosphate + NADH + H+
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+
-
 Mycobacterium tuberculosis H37Rv xanthosine 5'-phosphate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 guaB2
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.205 0.53
-
 inosine 5'-phosphate pH 8.0, 25°C Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+ comparison between the NAD+ binding sites of human IMPDHs and Mycobacterium tuberculosis IMPDH Homo sapiens
1.1.1.205 NAD+ comparison between the NAD+ binding-sites of human IMPDHs and Mycobacterium tuberculosis IMPDH Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.000034
-
 6-((E)-4-(((1-(50-deoxy-adenosin-50-yl)-1H-1,2,3-triazol-4-yl)-methyl)amino)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one pH 8.0, 25°C Homo sapiens
1.1.1.205 0.000044
-
 6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one pH 8.0, 25°C Homo sapiens
1.1.1.205 0.00007
-
 6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one pH 8.0, 25°C Homo sapiens
1.1.1.205 0.000077
-
 6-((E)-4-(((1-(50-deoxy-adenosin-50-yl)-1H-1,2,3-triazol-4-yl)-methyl)amino)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one pH 8.0, 25°C Homo sapiens
1.1.1.205 0.0015
-
 6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one pH 8.0, 25°C Mycobacterium tuberculosis
1.1.1.205 5
-
 NAD+ pH 8.0, 25°C Mycobacterium tuberculosis