EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | Cd2+ | non-competitive inhibition with respect to both NADPH and GSSG | Bos taurus | |
1.8.1.7 | additional information | glutathione reductase is not influenced by Al3+, Ba2+, Mn2+, and Li+ at 0.01-0.1 mM, and by Ca2+ and Mo6+ at 0.005-0.125 mM | Bos taurus | |
1.8.1.7 | Ni2+ | non-competitive inhibition with respect to GSSG and uncompetitive inhibition with respect to NADPH | Bos taurus | |
1.8.1.7 | Zn2+ | non-competitive inhibition with respect to both NADPH and GSSG | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.7 | Bos taurus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.7 | liver | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | GSSG + NADPH + H+ | - |
Bos taurus | glutathione + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.7 | EC 1.6.4.2 | formerly | Bos taurus |
1.8.1.7 | glutathione reductase | - |
Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | FAD | - |
Bos taurus | |
1.8.1.7 | NADPH | - |
Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.7 | 0.113 | - |
Cd2+ | with NADPH as the varied substrate, pH 7.4, 37°C | Bos taurus | |
1.8.1.7 | 0.221 | - |
Cd2+ | with GSSG as the varied substrate, pH 7.4, 37°C | Bos taurus | |
1.8.1.7 | 0.313 | - |
Ni2+ | with GSSG as the varied substrate, pH 7.4, 37°C | Bos taurus | |
1.8.1.7 | 0.32 | - |
Zn2+ | with GSSG as the varied substrate, pH 7.4, 37°C | Bos taurus | |
1.8.1.7 | 0.761 | - |
Zn2+ | with NADPH as the varied substrate, pH 7.4, 37°C | Bos taurus | |
1.8.1.7 | 0.932 | - |
Ni2+ | with NADPH as the varied substrate, pH 7.4, 37°C | Bos taurus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.8.1.7 | 0.08 | - |
pH 7.4, 37°C | Bos taurus | Cd2+ | |
1.8.1.7 | 0.8 | - |
pH 7.4, 37°C | Bos taurus | Ni2+ | |
1.8.1.7 | 1 | - |
pH 7.4, 37°C | Bos taurus | Zn2+ |