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Literature summary extracted from

  • Puchi, M.; Garcia-Huidobro, J.; Cordova, C.; Aguilar, R.; Dufey, E.; Imschenetzky, M.; Bustos, P.; Morin, V.
    A new nuclear protease with cathepsin L properties is present in Hela and Caco-2 cells (2010), J. Cell. Biochem., 111, 1099-1106.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
 Homo sapiens
3.4.22.15 E-64d
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.15 cytoplasm the protease translocates to the cytoplasm in non proliferative cells Homo sapiens 5737
-
3.4.22.15 nucleus the protease associates to the mitotic spindle during mitosis and remains in the nuclei in binuclear cells Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.15 60000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.15 histone H1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.15 partial purification by Superdex-75 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 Caco-2 cell
-
 Homo sapiens
-
3.4.22.15 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.15 histone H1 + H2O
-
 Homo sapiens ?
-
 ?