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Literature summary extracted from

  • Schut, G.J.; Adams, M.W.
    The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production (2009), J. Bacteriol., 191, 4451-4457.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.12.1.2 0.00025
-
 reduced ferredoxin pH and temperature not specified in the publication Thermotoga maritima

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.12.1.2 cytoplasm
-
 Thermotoga maritima 5737
-
1.12.1.4 cytoplasm
-
 Thermotoga maritima 5737
-
1.12.7.2 cytoplasm
-
 Thermotoga maritima 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.12.1.4 NADH + H+ + reduced ferredoxin Thermotoga maritima the iron hydrogenase requires the presence of both electron carriers, NADH and ferredoxin, for catalysis of H2 production H2 + NAD+ + oxidized ferredoxin
-
 ?
1.12.1.4 NADH + H+ + reduced ferredoxin Thermotoga maritima DSM 3109 the iron hydrogenase requires the presence of both electron carriers, NADH and ferredoxin, for catalysis of H2 production H2 + NAD+ + oxidized ferredoxin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.12.1.2 Thermotoga maritima
-
-
-
1.12.1.4 Thermotoga maritima
-
-
-
1.12.1.4 Thermotoga maritima DSM 3109
-
-
-
1.12.7.2 Thermotoga maritima
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.1.2 H+ + NADH + reduced ferredoxin the hydrogenase requires the presence of both electron carriers, NADH and reduced ferredoxin, synergistically in a 1:1 ratio for catalysis of H2 production Thermotoga maritima H2 + NAD+ + oxidized ferredoxin
-
 ?
1.12.1.2 H+ + NADH + reduced ferredoxin the hydrogenase requires the presence of both electron carriers, NADH and reduced ferredoxin, synergistically in a 1:1 ratio for catalysis of H2 production Thermotoga maritima DSM 3109 H2 + NAD+ + oxidized ferredoxin
-
 ?
1.12.1.2 H+ + reduced dithionite
-
 Thermotoga maritima H2 + oxidized dithionite
-
 ?
1.12.1.2 H+ + reduced dithionite
-
 Thermotoga maritima DSM 3109 H2 + oxidized dithionite
-
 ?
1.12.1.2 H+ + reduced methyl viologen
-
 Thermotoga maritima H2 + oxidized methyl viologen
-
 ?
1.12.1.2 H+ + reduced methyl viologen
-
 Thermotoga maritima DSM 3109 H2 + oxidized methyl viologen
-
 ?
1.12.1.4 NADH + H+ + reduced ferredoxin the iron hydrogenase requires the presence of both electron carriers, NADH and ferredoxin, for catalysis of H2 production Thermotoga maritima H2 + NAD+ + oxidized ferredoxin
-
 ?
1.12.1.4 NADH + H+ + reduced ferredoxin the iron hydrogenase requires the presence of both electron carriers, NADH and ferredoxin, for catalysis of H2 production Thermotoga maritima DSM 3109 H2 + NAD+ + oxidized ferredoxin
-
 ?
1.12.1.4 NADH + H+ + reduced methyl viologen
-
 Thermotoga maritima H2 + NAD+ + oxidized methyl viologen
-
 ?
1.12.7.2 H2 + oxidized ferredoxin
-
 Thermotoga maritima H+ + reduced ferredoxin
-
 ?
1.12.7.2 H2 + oxidized ferredoxin
-
 Thermotoga maritima DSM 3109 H+ + reduced ferredoxin
-
 ?

Subunits

EC Number Subunits Comment Organism
1.12.1.4 heterotrimer
-
 Thermotoga maritima
1.12.7.2 monomer
-
 Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
1.12.1.2 H2ase
-
 Thermotoga maritima
1.12.1.2 iron-hydrogenase
-
 Thermotoga maritima
1.12.1.2 [FeFe] hydrogenase
-
 Thermotoga maritima
1.12.1.4 bifurcating [FeFe] hydrogenase
-
 Thermotoga maritima
1.12.1.4 iron hydrogenase
-
 Thermotoga maritima
1.12.1.4 [FeFe]-type hydrogenase
-
 Thermotoga maritima
1.12.7.2 ferredoxin-dependent [FeFe] hydrogenase
-
 Thermotoga maritima
1.12.7.2 [FeFe]-hydrogenase
-
 Thermotoga maritima

Cofactor

EC Number Cofactor Comment Organism Structure
1.12.1.2 Ferredoxin the hydrogenase requires the presence of both electron carriers, NADH and reduced ferredoxin, synergistically for catalysis of H2 production Thermotoga maritima
1.12.1.2 FMN
-
 Thermotoga maritima
1.12.1.2 NADH the hydrogenase requires the presence of both electron carriers, NADH and reduced ferredoxin, synergistically for catalysis of H2 production Thermotoga maritima
1.12.1.4 FMN
-
 Thermotoga maritima
1.12.1.4 iron-sulfur centre the alpha subunit contains two [2Fe-2S] clusters and three [4Fe-4S] clusters, the beta subunit contains three [4Fe-4S] clusters and one [2Fe-2S] clusters, the gamma subunit contains one [2Fe-2S] cluster Thermotoga maritima
1.12.7.2 Ferredoxin
-
 Thermotoga maritima