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Literature summary extracted from

  • Lin, P.C.; Turk, K.; Hase, C.C.; Fritz, G.; Steuber, J.
    Quinone reduction by the Na+-translocating NADH dehydrogenase promotes extracellular superoxide production in Vibrio cholerae (2007), J. Bacteriol., 189, 3902-3908.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.1.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
 Vibrio cholerae serotype O1
7.2.1.1 Ag+ in the presence of Ag+, rates of NADH oxidation by membranes from the parent Vibrio cholera strain decrease to 14% (0.001 mM Ag+) of the activity observed in the absence of the inhibitor Vibrio cholerae serotype O1

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.1.1 membrane
-
 Vibrio cholerae serotype O1 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.1.1 Na+ environmental Na+ can stimulate ubisemiquinone formation by the Na+-NQR and hereby enhances the production of reactive oxygen species formed during the autoxidation of reduced quinines, increasing the Na+ concentration from below 0.1 mM to 25 mM results in a 3fold stimulation of activity of the purified enzyme Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.1.1 NADH + H+ + ubiquinone + Na+/in Vibrio cholerae serotype O1
-
 NAD+ + ubiquinol + Na+/out
-
 ?
7.2.1.1 NADH + H+ + ubiquinone + Na+/in Vibrio cholerae serotype O1 ATCC 39541
-
 NAD+ + ubiquinol + Na+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.1.1 Vibrio cholerae serotype O1 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
-
7.2.1.1 Vibrio cholerae serotype O1 ATCC 39541 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.1.1 NADH + H+ + ubiquinone + Na+/in
-
 Vibrio cholerae serotype O1 NAD+ + ubiquinol + Na+/out
-
 ?
7.2.1.1 NADH + H+ + ubiquinone + Na+/in
-
 Vibrio cholerae serotype O1 ATCC 39541 NAD+ + ubiquinol + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.1.1 Na+-NQR
-
 Vibrio cholerae serotype O1
7.2.1.1 Na+-translocating NADH:quinone oxidoreductase
-
 Vibrio cholerae serotype O1

Cofactor

EC Number Cofactor Comment Organism Structure
7.2.1.1 FAD
-
 Vibrio cholerae serotype O1
7.2.1.1 FMN
-
 Vibrio cholerae serotype O1
7.2.1.1 NADH
-
 Vibrio cholerae serotype O1
7.2.1.1 riboflavin
-
 Vibrio cholerae serotype O1
7.2.1.1 ubiquinone-8
-
 Vibrio cholerae serotype O1
7.2.1.1 [2Fe-2S]-center the NqrF subunit of the Na+-NQR complex harbors a [2Fe-2S] cluster which accepts electrons from the FAD cofactor Vibrio cholerae serotype O1

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.1.1 0.0001
-
 pH and temperature not specified in the publication Vibrio cholerae serotype O1 Ag+