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Literature summary extracted from

  • Konjar, S.; Sutton, V.R.; Hoves, S.; Repnik, U.; Yagita, H.; Reinheckel, T.; Peters, C.; Turk, V.; Turk, B.; Trapani, J.A.; Kopitar-Jerala, N.
    Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L (2010), Immunology, 131, 257-267.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
 Homo sapiens
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone
-
 Mus musculus
3.4.22.15 E-64d
-
 Homo sapiens
3.4.22.15 E-64d
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.15 lysosome
-
 Mus musculus 5764
-
3.4.22.15 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.15 perforin + H2O Mus musculus CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus ?
-
 ?
3.4.22.15 perforin + H2O Homo sapiens CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Homo sapiens
-
-
-
3.4.22.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 cytotoxic T-lymphocyte
-
 Mus musculus
-
3.4.22.15 natural killer cell
-
 Homo sapiens
-
3.4.22.15 NK-92 cell
-
 Homo sapiens
-
3.4.22.15 YT cell YT 5 cell Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.15 benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.15 perforin + H2O CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus Mus musculus ?
-
 ?
3.4.22.15 perforin + H2O CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.15 CatL
-
 Mus musculus
3.4.22.15 CatL
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.22.15 physiological function granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process Mus musculus
3.4.22.15 physiological function granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process Homo sapiens