BRENDA - Enzyme Database

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

Jansen, R.S.; Rosing, H.; Schellens, J.H.; Beijnen, J.H.; Fundam. Clin. Pharmacol. 25, 172-185 (2011)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCMP
allosterically increases dCMPD activity
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dGMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
dTTP
inhibits dCMPD by allosteric interaction
Homo sapiens
3.5.4.12
dUMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
GMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
additional information
monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as inhibitors of dCMPD
Homo sapiens
3.5.4.12
tetrahydrodeoxyuridine
-
Homo sapiens
3.5.4.12
TTP
inhibits dCMPD by allosteric interaction
Homo sapiens
3.5.4.12
zebularine
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
-
dUMP + NH3
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.12
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
(+)-FTCMP + H2O
-
712083
Homo sapiens
?
-
-
-
?
3.5.4.12
2',3'-dideoxy-5-fluoro-3'-thiacytidine + H2O
good substrate
712083
Homo sapiens
?
-
-
-
?
3.5.4.12
5-aza-dCMP + H2O
-
712083
Homo sapiens
5-aza-dUMP + NH3
-
-
-
?
3.5.4.12
ara-CMP + H2O
fair substrate
712083
Homo sapiens
ara-UMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
-
712083
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
cytidine monophosphate is not a good substrate for dCMPD. Monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as substrates of dCMPD
712083
Homo sapiens
?
-
-
-
-
3.5.4.12
PSI-6130-MP + H2O
weak substrate
712083
Homo sapiens
?
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCMP
allosterically increases dCMPD activity
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dGMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
dTTP
inhibits dCMPD by allosteric interaction
Homo sapiens
3.5.4.12
dUMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
GMP
potent competitive inhibitor
Homo sapiens
3.5.4.12
additional information
monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as inhibitors of dCMPD
Homo sapiens
3.5.4.12
tetrahydrodeoxyuridine
-
Homo sapiens
3.5.4.12
TTP
inhibits dCMPD by allosteric interaction
Homo sapiens
3.5.4.12
zebularine
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
-
dUMP + NH3
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
(+)-FTCMP + H2O
-
712083
Homo sapiens
?
-
-
-
?
3.5.4.12
2',3'-dideoxy-5-fluoro-3'-thiacytidine + H2O
good substrate
712083
Homo sapiens
?
-
-
-
?
3.5.4.12
5-aza-dCMP + H2O
-
712083
Homo sapiens
5-aza-dUMP + NH3
-
-
-
?
3.5.4.12
ara-CMP + H2O
fair substrate
712083
Homo sapiens
ara-UMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
-
712083
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
cytidine monophosphate is not a good substrate for dCMPD. Monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as substrates of dCMPD
712083
Homo sapiens
?
-
-
-
-
3.5.4.12
PSI-6130-MP + H2O
weak substrate
712083
Homo sapiens
?
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.5.4.12
metabolism
dCMPD is pivotal in deoxyuridine analogs nucleotide formation
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.5.4.12
metabolism
dCMPD is pivotal in deoxyuridine analogs nucleotide formation
Homo sapiens