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Literature summary extracted from

  • Jansen, R.S.; Rosing, H.; Schellens, J.H.; Beijnen, J.H.
    Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites? (2011), Fundam. Clin. Pharmacol., 25, 172-185.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 dCMP allosterically increases dCMPD activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.12 dGMP potent competitive inhibitor Homo sapiens
3.5.4.12 dTTP inhibits dCMPD by allosteric interaction Homo sapiens
3.5.4.12 dUMP potent competitive inhibitor Homo sapiens
3.5.4.12 GMP potent competitive inhibitor Homo sapiens
3.5.4.12 additional information monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as inhibitors of dCMPD Homo sapiens
3.5.4.12 tetrahydrodeoxyuridine
-
 Homo sapiens
3.5.4.12 TTP inhibits dCMPD by allosteric interaction Homo sapiens
3.5.4.12 zebularine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Homo sapiens
-
 dUMP + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 (+)-FTCMP + H2O
-
 Homo sapiens ?
-
 ?
3.5.4.12 2',3'-dideoxy-5-fluoro-3'-thiacytidine + H2O good substrate Homo sapiens ?
-
 ?
3.5.4.12 5-aza-dCMP + H2O
-
 Homo sapiens 5-aza-dUMP + NH3
-
 ?
3.5.4.12 ara-CMP + H2O fair substrate Homo sapiens ara-UMP + NH3
-
 ?
3.5.4.12 dCMP + H2O
-
 Homo sapiens dUMP + NH3
-
 ?
3.5.4.12 additional information cytidine monophosphate is not a good substrate for dCMPD. Monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as substrates of dCMPD Homo sapiens ?
-
 ?
3.5.4.12 PSI-6130-MP + H2O weak substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.12 dCMPD
-
 Homo sapiens
3.5.4.12 deoxycytidine monophosphate deaminase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.4.12 metabolism dCMPD is pivotal in deoxyuridine analogs nucleotide formation Homo sapiens