Literature summary extracted from
Moon, K.H.; Lee, Y.M.; Song, B.J.
Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation (2010), Free Radic. Biol. Med., 48, 391-398.
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.2.1.3 |
c-Jun N-terminal protein kinase |
incubation with catalytically active JNK leads to significant inhibition of ALDH2 activity. CCl4 exposure activates JNK which translocates to mitochondria and phosphorylates ALDH2 contributing to inhibition of ALDH2 activity |
Rattus norvegicus |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
1.2.1.3 |
mitochondrion |
isoform ALDH2 |
Rattus norvegicus |
5739 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.2.1.3 |
Rattus norvegicus |
P11884 |
- |
- |
Posttranslational Modification
EC Number |
Posttranslational Modification |
Comment |
Organism |
---|
1.2.1.3 |
phosphoprotein |
CCl4 exposure activates JNK, which translocates to mitochondria and phosphorylates ALDH2 |
Rattus norvegicus |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
1.2.1.3 |
hepatocyte |
- |
Rattus norvegicus |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.2.1.3 |
propionaldehyde + NAD+ + H2O |
- |
Rattus norvegicus |
propionate + NADH + H+ |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.2.1.3 |
ALDH2 |
isoform |
Rattus norvegicus |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
1.2.1.3 |
NAD+ |
- |
Rattus norvegicus |
|
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.2.1.3 |
malfunction |
inhibition of ALDH2 leads to accumulation of cytotoxic 4-hydroxynonenal and malondialdehyde, which can cause cell death through activation of c-Jun N-terminal protein kinase and/or p38 kinase |
Rattus norvegicus |