Literature summary extracted from

Westphal, K.; Stangl, V.; Faehling, M.; Dreger, H.; Weller, A.; Baumann, G.; Stangl, K.; Meiners, S.
Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells (2009), Free Radic. Biol. Med., 47, 1652-1660.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.11.1.9	glutathione + ROOH	Homo sapiens	-	glutathione disulfide + ROH + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.11.1.9	Homo sapiens	P22352	-	-
1.11.1.9	no activity in Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.11.1.9	aortic smooth muscle cell	GPx-3 is detected at very low levels under basal conditions	Homo sapiens	-
1.11.1.9	HAEC cell	GPx-3 is detected at very low levels under basal conditions	Homo sapiens	-
1.11.1.9	HUVEC cell	GPx-3 is detected at very low levels under basal conditions	Homo sapiens	-
1.11.1.9	plasma	GPx-3 is secreted into the plasma	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.11.1.9	glutathione + ROOH	-	Homo sapiens	glutathione disulfide + ROH + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.11.1.9	glutathione peroxidase-3	-	Homo sapiens
1.11.1.9	GPx-3	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
1.11.1.9	Homo sapiens	GPx-3 is induced by MG132 in HUVEC cells with an exponential increase in GPx-3 mRNA up to 120fold of control levels within 48 h. GPx-3 is still upregulated by a factor of 3-4 even after 72 and 96 h of proteasome inhibition. HAEC cells upregulate GPx-3 by more than 40fold in response to MG132. Proteasome inhibition clearly induces GPx-3 in HAoSMCs by a factor of 18	up

General Information

EC Number	General Information	Comment	Organism
1.11.1.9	physiological function	glutathione peroxidase-3 is a key antioxidant enzyme in the plasma. Endothelial cell-derived GPx-3 protects the vasculature from oxidative stress	Homo sapiens

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Release 2023.1 (January 2023)