Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Carvalho, C.M.; Lu, J.; Zhang, X.; Arner, E.S.; Holmgren, A.
    Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning (2011), FASEB J., 25, 370-381.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 Hg2+ in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity Homo sapiens
1.8.1.9 Hg2+ in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity Rattus norvegicus
1.8.1.9 methylmercury in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme Homo sapiens
1.8.1.9 methylmercury in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 58000
-
2 * 58000, SDS-PAGE Homo sapiens
1.8.1.9 58000
-
2 * 58000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens
-
-
-
1.8.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 insulin + NADPH + H+
-
Homo sapiens ? + NADP+
-
?
1.8.1.9 insulin + NADPH + H+
-
Rattus norvegicus ? + NADP+
-
?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
Homo sapiens thioredoxin + NADP+
-
?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Subunits

EC Number Subunits Comment Organism
1.8.1.9 homodimer 2 * 58000, SDS-PAGE Homo sapiens
1.8.1.9 homodimer 2 * 58000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
Homo sapiens
1.8.1.9 thioredoxin reductase
-
Rattus norvegicus
1.8.1.9 TrxR
-
Homo sapiens
1.8.1.9 TrxR
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
Homo sapiens
1.8.1.9 FAD
-
Rattus norvegicus
1.8.1.9 NADPH
-
Homo sapiens
1.8.1.9 NADPH
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.8.1.9 physiological function the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage Homo sapiens
1.8.1.9 physiological function the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage Rattus norvegicus