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Literature summary extracted from

  • Allen, E.M.; Anderson, D.G.; Florang, V.R.; Khanna, M.; Hurley, T.D.; Doorn, J.A.
    Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition (2010), Chem. Res. Toxicol., 23, 1843-1850.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.3 C302S no reactivity is observed for either molinate or molinate sulfone with the C302S mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 molinate irreversible inhibition of ALDH2 Homo sapiens
1.2.1.3 molinate sulfoxide i.e. S-ethyl-hexahydro-1H-azepine-1-carbothioate sulfoxide, irreversible inhibition of ALDH2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 0.375
-
 recombinant enzyme, using propionaldehyde as the substrate, in 50 mM sodium phosphate buffer, pH 7.4, at 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 propionaldehyde + NAD+ + H2O
-
 Homo sapiens propionate + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase 2
-
 Homo sapiens
1.2.1.3 ALDH2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens