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Literature summary extracted from

  • Shin, V.Y.; Jin, H.C.; Ng, E.K.; Sung, J.J.; Chu, K.M.; Cho, C.H.
    Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth (2010), Cancer Lett., 292, 237-245.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 5-LOX activating protein
-
 Homo sapiens
1.13.11.34 Nicotine treatment with 0.01 mM nicotine activates 5-lipoxygenase gastric cancer cell lines from 36-72 h Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 MK886 5-LOX activating protein inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
 leukotriene A4 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 AGS cell
-
 Homo sapiens
-
1.13.11.34 MKN-28 cell
-
 Homo sapiens
-
1.13.11.34 MKN-45 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 5-LOX
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.34 malfunction blockade of 5-LOX signaling results in downregulation of cyclin D1, matrix metalloproteinase (MMP-7, -9), urokinase plasminogen activator and its receptor, and pro-apoptotic proteins Homo sapiens
1.13.11.34 physiological function activation of 5-LOX modulates the G1/S phase transition regulatory proteins and causes cell proliferation Homo sapiens