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Literature summary extracted from

  • Fischer, A.S.; Metzner, J.; Steinbrink, S.D.; Ulrich, S.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Maier, T.J.
    5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity (2010), Br. J. Pharmacol., 161, 936-949.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.13.11.34 medicine direct 5-LO inhibitors are able to suppress the viability of various human tumour cells independently of 5-LO inhibition Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 AA-861 competitive 5-LO inhibitor Homo sapiens
1.13.11.34 BWA4C
-
 Homo sapiens
1.13.11.34 CJ-13,610
-
 Homo sapiens
1.13.11.34 MK-886 competitive 5-LO inhibitor Homo sapiens
1.13.11.34 Rev-5901 competitive 5-LO inhibitor Homo sapiens
1.13.11.34 zileuton
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.34 78000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 CAPAN-2 cell
-
 Homo sapiens
-
1.13.11.34 HeLa cell
-
 Homo sapiens
-
1.13.11.34 PANC-1 cell
-
 Homo sapiens
-
1.13.11.34 pancreatic cancer cell
-
 Homo sapiens
-
1.13.11.34 THP-1 cell
-
 Homo sapiens
-
1.13.11.34 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 5-LO
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.34 physiological function 5-LO products significantly contribute to tumour cell proliferation Homo sapiens