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Literature summary extracted from

  • Chiari, M.E.; Vera, D.M.; Palacios, S.M.; Carpinella, M.C.
    Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans (2011), Bioorg. Med. Chem., 19, 3474-3482.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone dalenin, the reversible inhibitor is 52 and 495times more effective as a monophenolase inhibitor than hydroquinone and kojic acid, respectively, non-competitive inhibitor with L-DOPA as substrate, mixed-I type inhibitor with L-tyrosine as substrate Agaricus bisporus
1.14.18.1 hydroquinone
-
Agaricus bisporus
1.14.18.1 kojic acid
-
Agaricus bisporus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.18.1 0.347
-
L-tyrosine in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus
1.14.18.1 1.44
-
L-Dopa in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2 monophenolase activity Agaricus bisporus dopaquinone + H2O
-
?
1.14.18.1 L-tyrosine + O2 diphenolase activity Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.00198
-
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus
1.14.18.1 0.16
-
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.00026
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus 5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
1.14.18.1 0.01348
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus hydroquinone
1.14.18.1 0.01857
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus kojic acid
1.14.18.1 0.01861
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus 5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
1.14.18.1 0.129
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus kojic acid
1.14.18.1 1.09
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C Agaricus bisporus hydroquinone