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Literature summary extracted from

  • Zimmermann, T.; Niesen, F.; Pilka, E.; Knapp, S.; Oppermann, U.; Maier, M.
    Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone (2009), Bioorg. Med. Chem., 17, 530-536.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.184 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione zearalenone analogue Homo sapiens
1.1.1.184 Biochanin A
-
 Homo sapiens
1.1.1.184 chrysin
-
 Homo sapiens
1.1.1.184 naringenin
-
 Homo sapiens
1.1.1.184 triclosan
-
 Homo sapiens
1.1.1.184 wedelolactone
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens
-
 carbonyl reductase 1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 isatin + NADPH + H+
-
 Homo sapiens 3-hydroxy-2-oxoindole + NADP+
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.184 0.00004
-
 14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.00006
-
 triclosan pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.00011
-
 chrysin pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.00052
-
 radiciol pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.0006
-
 wedelolactone pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.00203
-
 Biochanin A pH 6.9, temperature not specified in the publication Homo sapiens
1.1.1.184 0.00343
-
 naringenin pH 6.9, temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.184 0.00021
-
 pH 6.9, temperature not specified in the publication Homo sapiens 14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
1.1.1.184 0.0004
-
 pH 6.9, temperature not specified in the publication Homo sapiens triclosan
1.1.1.184 0.00067
-
 pH 6.9, temperature not specified in the publication Homo sapiens chrysin
1.1.1.184 0.00327
-
 pH 6.9, temperature not specified in the publication Homo sapiens radiciol
1.1.1.184 0.00378
-
 pH 6.9, temperature not specified in the publication Homo sapiens wedelolactone
1.1.1.184 0.0127
-
 pH 6.9, temperature not specified in the publication Homo sapiens Biochanin A
1.1.1.184 0.0215
-
 pH 6.9, temperature not specified in the publication Homo sapiens naringenin