EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.98 | 2,3-dihydrobenzoic acid | 98% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | 2-hydroxybutyric acid | 96% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | 3,4-Dihydroxyphenyl acetic acid | 90% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | 3-hydroxycinnamic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | 8-hydroxyquinoline | 85% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | Baclofen | 98% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | Butyric acid | - |
Homo sapiens | |
3.5.1.98 | caffeic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | chlorogenic acid | highly potent HDAC inhibitor, 40% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | Cinnamic acid | 95% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | curcumin | highly potent HDAC inhibitor, 52% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | D-(-)-quinic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | dihydrocaffeic acid | 86% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | ferulic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | gamma-aminobutyric acid | - |
Homo sapiens | |
3.5.1.98 | indol-2-carboxylic acid | 97% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | isobutyric acid | 80% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | Mandelic acid | 85% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | additional information | HDAC is not inhibited by isovaleric acid, L-valine, sodium lactate, succinic acid, citric acid, benzylic acid, hippuric acid, antranilic acid (2-aminobenzoic acid), alpha-hydroxyacetonaphthone, and kojic acid | Homo sapiens | |
3.5.1.98 | phenyl butyric acid | - |
Homo sapiens | |
3.5.1.98 | phenylbutyric acid | - |
Homo sapiens | |
3.5.1.98 | propionic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | salicylic acid | 92% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | sodium butyrate | - |
Homo sapiens | |
3.5.1.98 | sodium phenylbutyrate | - |
Homo sapiens | |
3.5.1.98 | sorbic acid | 91% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | suberoyl anilide hydroxamic acid | - |
Homo sapiens | |
3.5.1.98 | tartaric acid | 90% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | trichostatin A | - |
Homo sapiens | |
3.5.1.98 | Valeric acid | 83% residual activity at 0.5 mM | Homo sapiens | |
3.5.1.98 | Valproic acid | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.1.98 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.98 | Homo sapiens | Q9BY41 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.98 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.98 | tert-butyloxycarbonyl-L-Lys(acetyl)-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-L-Lys-7-amido-4-methylcoumarin + acetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.98 | HDAC8 | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.98 | 0.00000821 | - |
Cinnamic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.000135 | - |
chlorogenic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.000504 | - |
trichostatin A | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.000539 | - |
curcumin | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.00247 | - |
suberoyl anilide hydroxamic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.0028 | - |
phenyl butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.00634 | - |
sodium phenylbutyrate | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.00819 | - |
gamma-aminobutyric acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.01084 | - |
caffeic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.136 | - |
Butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.365 | - |
sodium butyrate | pH and temperature not specified in the publication | Homo sapiens | |
3.5.1.98 | 0.564 | - |
Valproic acid | pH and temperature not specified in the publication | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.1.98 | 0.115 | - |
pH and temperature not specified in the publication | Homo sapiens | curcumin | |
3.5.1.98 | 0.375 | - |
pH and temperature not specified in the publication | Homo sapiens | chlorogenic acid | |
3.5.1.98 | 2.54 | - |
pH and temperature not specified in the publication | Homo sapiens | caffeic acid |