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Literature summary extracted from

  • Nolan, K.A.; Caraher, M.C.; Humphries, M.P.; Bettley, H.A.; Bryce, R.A.; Stratford, I.J.
    In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2) (2010), Bioorg. Med. Chem. Lett., 20, 7331-7336.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 NSC106080 i.e. bis(2-hydroxyphenyl)methanone phenylhydrazone Homo sapiens
1.10.5.1 NSC115890 i.e. 1,3-naphthalenediol Homo sapiens
1.10.5.1 NSC180969 i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-benzo[e]isoindol-3-one Homo sapiens
1.10.5.1 NSC187208 i.e. N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine, chloroquine Homo sapiens
1.10.5.1 NSC204996 i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-benzo[e]isoindole Homo sapiens
1.10.5.1 NSC238146 i.e. N4-(6-((6-amino-2-methyl-4-quinolinyl)amino)hexyl)-2-methyl-4,6-quinolinediamine acetate Homo sapiens
1.10.5.1 NSC27296 i.e. N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine, primaquine Homo sapiens
1.10.5.1 NSC300853 i.e. 3-amino-9-ethyl-2-((4-(hydroxy(oxido)amino)phenyl)diazenyl)-9H-carbazole Homo sapiens
1.10.5.1 NSC306843 i.e. 1-methyl-4(1H)-quinolinone (1-methyl-4(1H)-quinolinylidene)hydrazone Homo sapiens
1.10.5.1 NSC332172 i.e. 2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile Homo sapiens
1.10.5.1 NSC356819 i.e. 4-((2-hydroxy-5-(phenyldiazenyl)phenyl)diazenyl)benzenecarboximidamide Homo sapiens
1.10.5.1 NSC356820 i.e. 4-((2-hydroxy-5-(2-phenylvinyl)phenyl)diazenyl)benzenecarboximidamide Homo sapiens
1.10.5.1 NSC359466 i.e. 4-((4-(amino(imino)methyl)phenyl)diazenyl)-3-hydroxy-N-phenyl-2-naphthamide Homo sapiens
1.10.5.1 NSC381864 i.e. 5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenol Homo sapiens
1.10.5.1 NSC621351 i.e. 2-(2-fluorophenyl)-4-(2-naphthyl)-2,3-dihydro-1,5-benzothiazepine Homo sapiens
1.10.5.1 NSC623234 i.e. 3-chloro-3-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylaldehyde Homo sapiens
1.10.5.1 NSC640353 i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-4-methyl-5-phenyl-2,4-pentadien-1-one Homo sapiens
1.10.5.1 NSC640556 i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-(hydroxy(oxido)amino)phenyl)-2-propen-1-one Homo sapiens
1.10.5.1 NSC640558 i.e 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-phenyl-2-propen-1-one Homo sapiens
1.10.5.1 NSC640559 i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(3-(hydroxy(oxido)amino)phenyl)-2-propen-1-one Homo sapiens
1.10.5.1 NSC640566 i.e. 3-(4-chlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one Homo sapiens
1.10.5.1 NSC640583 i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-methylphenyl)-2-propen-1-one Homo sapiens
1.10.5.1 NSC640584 i.e. 3-(3,4-dichlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one Homo sapiens
1.10.5.1 NSC648420 i.e. 1,2,3-trimethoxyphenanthro[2,3-d][1,3]dioxol-6-yl acetate Homo sapiens
1.10.5.1 NSC648422 i.e. 5-(1-methyl-2-(3,4,5-trimethoxyphenyl)vinyl)-1,3-benzodioxole Homo sapiens
1.10.5.1 NSC649091 i.e. 2-((diethylamino)methyl)-4-((10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino)phenol hydrochloride Homo sapiens
1.10.5.1 NSC65069 i.e. [1,1'-biphenyl]-2,3',4,5',6-pentol Homo sapiens
1.10.5.1 NSC660841 one of the most potent inhibitors of NQO2 Homo sapiens
1.10.5.1 NSC66167 i.e. [1,1'-biphenyl]-2,2',4,4'-tetrol Homo sapiens
1.10.5.1 NSC665126 i.e. 1-(2-(4-(hydroxy(oxido)amino)phenyl)vinyl)-3-phenylbenzo[f]quinoline Homo sapiens
1.10.5.1 NSC669977 i.e. 6-imino-1-methyl-3-phenyl-2,6-dihydro-5(1H)-quinolinone hydrazone Homo sapiens
1.10.5.1 NSC676468 i.e. N-(3-([1,10-biphenyl]-4-ylimino)-1-propenyl)[1,10-biphenyl]-4-amine Homo sapiens
1.10.5.1 NSC677939 i.e. 14H-diindolo[2,3-a:3,2-h]quinolizine Homo sapiens
1.10.5.1 NSC693571 i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-2-phenyl-4H-1lambda5-pyrazolo[1,5-a]indol-4-ylidene)methyl)aniline Homo sapiens
1.10.5.1 NSC720622 i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-6-nitro-2-phenylpyrazolo[1,5-a]indol-1-ium-4-ylidene)methyl)aniline Homo sapiens
1.10.5.1 NSC77833 i.e. 1-(2-(1H-indol-3-yl)vinyl)isoquinoline Homo sapiens
1.10.5.1 NSC78017 i.e. 2,6-dimethyl-3H-pyrrolo[3,2-f]quinoline Homo sapiens
1.10.5.1 NSC78021 i.e. 4,7-dimethyl-7H-pyrido[2,3-c]carbazole Homo sapiens
1.10.5.1 NSC86715 i.e. 5-methyl-1-phenyl-6H-pyrido[4,3-b]carbazole Homo sapiens
1.10.5.1 NSC97374 i.e. 1-ethyl-2-((1-ethyl-2(1H)-quinolinylidene)methyl)-1lambda5-quinoline Homo sapiens
1.10.5.1 NSC99495 i.e. 3-benzo[a]anthracen-12-ylthiophene Homo sapiens
1.10.5.1 NSC99528 i.e. 2-benzo[a]anthracen-12-yl-1-benzothiophene Homo sapiens
1.10.5.1 quercetin
-
 Homo sapiens
1.10.5.1 resveratrol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 N-benzyldihydronicotinamide + 2,6-dichlorophenolindophenol
-
 Homo sapiens N-benzylnicotinamide + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 NQO2
-
 Homo sapiens
1.10.5.1 NRH:quinone oxidoreductase 2
-
 Homo sapiens
1.10.5.1 quinone oxidoreductase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.5.1 0.0014
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC356820
1.10.5.1 0.0015
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC187208
1.10.5.1 0.0017
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC693571
1.10.5.1 0.0018
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC77833
1.10.5.1 0.0018
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC356819
1.10.5.1 0.0019
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC238146
1.10.5.1 0.002
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC180969
1.10.5.1 0.002
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC669977
1.10.5.1 0.0021
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC78017
1.10.5.1 0.0021
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC86715
1.10.5.1 0.0027
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC97374
1.10.5.1 0.0027
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC204996
1.10.5.1 0.0029
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC677939
1.10.5.1 0.0032
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640583
1.10.5.1 0.0033
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC115890
1.10.5.1 0.0035
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC649091
1.10.5.1 0.0038
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640353
1.10.5.1 0.0039
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC106080
1.10.5.1 0.0049
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640584
1.10.5.1 0.005
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC300853
1.10.5.1 0.005
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC720622
1.10.5.1 0.0051
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC99495
1.10.5.1 0.0053
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640566
1.10.5.1 0.0055
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC78021
1.10.5.1 0.0058
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC66167
1.10.5.1 0.0058
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640558
1.10.5.1 0.006
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC99528
1.10.5.1 0.006
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC359466
1.10.5.1 0.006
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640556
1.10.5.1 0.0062
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC306843
1.10.5.1 0.0065
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC640559
1.10.5.1 0.0075
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC27296
1.10.5.1 0.0096
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC665126
1.10.5.1 0.0097
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC676468
1.10.5.1 0.015
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC381864
1.10.5.1 0.02
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC332172
1.10.5.1 0.022
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens NSC623234