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Literature summary extracted from

  • Alcaro, S.; Gaspar, A.; Ortuso, F.; Milhazes, N.; Orallo, F.; Uriarte, E.; Yanez, M.; Borges, F.
    Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B (2010), Bioorg. Med. Chem. Lett., 20, 2709-2712.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 4-oxo-4H-chromene-3-carboxylic acid specific for MAO-B Homo sapiens
1.4.3.4 Clorgyline inhibits both MAO-A and MAO-B Homo sapiens
1.4.3.4 Iproniazide inhibits both MAO-A and MAO-B Homo sapiens
1.4.3.4 moclobemide specific for MAO-A Homo sapiens
1.4.3.4 additional information evaluation of chromone carboxylic acids as enzyme inhibitors, only chromone-3-carboxylic acid is a potent MAO-B inhibitor, with a high degree of selectivity for MAO-B compared to MAO-A, no inhibition by 4-oxo-4H-chromene-2-carboxylic acid at 0.1 mM, molecular docking, overview Homo sapiens
1.4.3.4 R-(-)-deprenyl inhibits both MAO-A and MAO-B Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.4 2-phenylethylamine + H2O + O2 Homo sapiens
-
 ?
-
 ?
1.4.3.4 benzylamine + H2O + O2 Homo sapiens
-
 benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 dopamine + H2O + O2 Homo sapiens
-
 ?
-
 ?
1.4.3.4 norepinephrine + H2O + O2 Homo sapiens
-
 ?
-
 ?
1.4.3.4 serotonin + H2O + O2 Homo sapiens substrate of MAO-A (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2 Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 2-phenylethylamine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.4 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 dopamine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.4 norepinephrine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.4 serotonin + H2O + O2 substrate of MAO-A Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens
1.4.3.4 monoamine oxidases A
-
 Homo sapiens
1.4.3.4 monoamine oxidases B
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 FAD
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.0000052
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens Clorgyline
1.4.3.4 0.000017
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens R-(-)-deprenyl
1.4.3.4 0.00656
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens Iproniazide
1.4.3.4 0.00754
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens Iproniazide
1.4.3.4 0.0634
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens Clorgyline
1.4.3.4 0.0687
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens R-(-)-deprenyl
1.4.3.4 0.3614
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens moclobemide