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Literature summary extracted from

  • Kot, M.; Karcz, W.; Zaborska, W.
    5-Hydroxy-1,4-naphthoquinone (juglone) and 2-hydroxy-1,4-naphthoquinone (lawsone) influence on jack bean urease activity: Elucidation of the difference in inhibition activity (2010), Bioorg. Chem., 38, 132-137.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 1,4-Naphthoquinone
-
 Canavalia ensiformis
3.5.1.5 5-hydroxy-1,4-naphthoquinone 5-hydroxy-1,4-naphthoquinone, juglone, acts as a strong, time and concentration dependent inactivator of urease. The reactivation of juglone-modified urease shows the participation of reversible and irreversible contribution in the inactivation. In the presence of an excess of DTT, urease inactivated by juglone regains 70% of its activity. The reversible inactivation is attributed to oxidation of the essential urease thiols by reactive oxygen species (ROS) realizing during reduction of juglone to seminaphthoquinone. The irreversible contribution in the inhibition is assumed as an arylation of urease thiol groups by juglone Canavalia ensiformis

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Canavalia ensiformis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Canavalia ensiformis CO2 + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.5 urease
-
 Canavalia ensiformis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.5 7.7
-
 assay at Canavalia ensiformis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 0.025
-
 pH 7.7, temperature not provided Canavalia ensiformis 5-hydroxy-1,4-naphthoquinone
3.5.1.5 0.03
-
 pH 7.7, temperature not provided Canavalia ensiformis 1,4-Naphthoquinone