Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, S.; Zhang, J.; Li, J.; Chen, D.; Matteucci, M.; Curd, J.; Duan, J.X.
    Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302 (2010), Biol. Trace Elem. Res., 136, 294-301.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 TH-302 TH-302 at 300 mg/kg significantly inhibits glutathione reductase activity by 60% as compared with the controls, at 3 h after the injection Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+ Mus musculus
-
 glutathione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Mus musculus glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Mus musculus
1.8.1.7 NADPH
-
 Mus musculus