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Literature summary extracted from

  • De Souza, A.M.; de Carvalho, T.L.; Lara, L.d.a..S.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    The stimulatory effect of angiotensin II on Na+-ATPase activity involves sequential activation of phospholipases and sustained PKC activity (2010), Biochim. Biophys. Acta, 1798, 354-359.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.3 angiotensin II stimulates the proximal tubule Na+-ATPase through the AT1 receptor/phosphoinositide phospholipase Cbeta/protein kinase C pathway, molecular mechanisms, overview. Ang II induces fast and correlated activation of Na+-ATPase and PKC activities with the maximal effect of 115% activation observed at 1 min and sustained for 30 min. Involvement of phospholipase A2, PLA2, on the modulation of Na+-ATPase activity by Ang II, and modulation of the effect of Ang II on Na+-ATPase activity by PLA2 inhibitors, e.g. quinacrine, PACOCF3 and a specific inhibitor, BEL, overview Sus scrofa
7.2.2.3 lysophosphatidic acid stimulates the enzyme to 120% at 0.01 nM. Protein kinase C mediates the modulation of Na+-ATPase activity by lysophosphatidic acid Sus scrofa
7.2.2.3 additional information phopshatidic acid stimulates the enzyme via activation of phospholipase A2, PLA2, which is inhibited by specific PLA2 inhibitors, overview Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
 Sus scrofa 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.3 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.3 native enzyme from kidney cortex and basolateral membranes from renal outer cortex Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Sus scrofa
-
7.2.2.3 renal tubule basolateral membranes from the outer cortex Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.3 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7
-
 assay at Sus scrofa