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Literature summary extracted from

  • Stoner, C.S.; Pearson, G.D.; Koc, A.; Merwin, J.R.; Lopez, N.I.; Merrill, G.F.
    Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast (2009), Biochemistry, 48, 9156-9169.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Saccharomyces cerevisiae
-
-
-
1.8.1.9 Saccharomyces cerevisiae W303-1A
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Saccharomyces cerevisiae thioredoxin + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Saccharomyces cerevisiae W303-1A thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase 1
-
 Saccharomyces cerevisiae
1.8.1.9 Trr1
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Saccharomyces cerevisiae
1.8.1.9 NADPH
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.8.1.9 malfunction reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Decreased reporter gene activity in thioredoxin reductase null cells is due to reduced p53 specific activity rather than reduced p53 protein levels Saccharomyces cerevisiae