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Literature summary extracted from

  • Song, K.H.; Kang, Y.J.; Jin, U.H.; Park, Y.I.; Kim, S.M.; Seong, H.H.; Hwang, S.; Yang, B.S.; Im, G.S.; Min, K.S.; Kim, J.H.; Chang, Y.C.; Kim, N.H.; Lee, Y.C.; Kim, C.H.
    Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation (2010), Biochem. J., 427, 179-188.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.2 expressed in pig kidney PK15 cells and human vascular endothelial ECV304 cells Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Sus scrofa A8WAC5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 colon
-
 Sus scrofa
-
1.14.18.2 intestine cDNA generated from, mRNA highly expressed Sus scrofa
-
1.14.18.2 rectum
-
 Sus scrofa
-
1.14.18.2 spleen
-
 Sus scrofa
-
1.14.18.2 tongue
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 additional information ectopic expression of pcmah in pig kidney PK15 cells and human vascular endothelial ECV304 cells leads to an elevated expression of N-glycolylneuraminic acid Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.2 CMP-Neu5Ac hydroxylase
-
 Sus scrofa
1.14.18.2 pcmah
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
1.14.18.2 malfunction pcmah silencing by short hairpin RNA results in a decrease in N-glycolylneuraminic acid content and xenoantigenicity in pig kidney PK15 cells Sus scrofa