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Literature summary extracted from
- Thioredoxin and thioredoxin reductase: current research with special reference to human disease (2010), Biochem. Biophys. Res. Commun., 396, 120-124.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | medicine | TrxR is a target for cancer chemotherapy | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus |  |
| 1.8.1.9 | curcumin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.9 | cytosol | isoform TrxR1 | Rattus norvegicus | 5829 | - |
| 1.8.1.9 | mitochondrion | isoform TrxR2 | Rattus norvegicus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | selenium | all three isoenzymes of mammalian TrxR contain an essential selenocysteine residue, which is the target of several drugs in cancer treatment or mercury intoxication | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.9 | 56000 | - |
2 * 56000 | Rattus norvegicus |
| 1.8.1.9 | 112000 | - |
- |
Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | liver | - |
Rattus norvegicus | - |
| 1.8.1.9 | testis | isoform TrxR3 is primarily present in testis | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | homodimer | 2 * 56000 | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | thioredoxin reductase | - |
Rattus norvegicus |
| 1.8.1.9 | TrxR | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | FAD | - |
Rattus norvegicus | |
| 1.8.1.9 | NADPH | - |
Rattus norvegicus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | physiological function | the thioredoxin system has a large number of functions in DNA synthesis, defense against oxidative stress and apoptosis or redox signaling with reference to many diseases | Rattus norvegicus |
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Release 2023.1 (January 2023)
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