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Literature summary extracted from

  • Cheng, C.; Tempel, D.; van Haperen, R.; van Damme, L.; Alguer, M.; Krams, R.; de Crom, R.
    Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype (2009), Atherosclerosis, 204, 26-33.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.B4 angiotensin II
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B4 extracellular matrix
-
 Mus musculus 31012
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B4 Collagen type I + H2O Mus musculus Interstitial fibers of collagen type I in the plaque can be degraded by MMP13 specifically. MMP13 is capable of degrading collagen type I in the upstream atherosclerotic lesions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B4 Mus musculus
-
 mice deficient in apolipopotein E (apoE -/-) in a C57BL/6J background
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B4 cartilage
-
 Mus musculus
-
3.4.24.B4 chondrocyte articular Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B4 Collagen type I + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B4 Collagen type I + H2O Interstitial fibers of collagen type I in the plaque can be degraded by MMP13 specifically. MMP13 is capable of degrading collagen type I in the upstream atherosclerotic lesions Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B4 MMP13
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.B4 additional information angiotensin II promotes a stable fibrotic phenotype by inducing severe intra-plaque hemorrhages, characterized by increased degradation of interstitial collagen I via an MMP13 or MMP8-mediated mechanism, overview Mus musculus