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Literature summary extracted from

  • Cabral, L.M.; Wengert, M.; Almeida, F.G.; Caruso-Neves, C.; Vieyra, A.; Einicker-Lamas, M.
    Ceramide-activated protein kinases A and C zeta inhibit kidney proximal tubule cell Na+-ATPase (2010), Arch. Biochem. Biophys., 498, 57-61.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 ceramide mediates enzyme inhibition to about 60% by activating protein kinase A and protein kinase Czeta, that regulate ion transporter activities. Inhibition of the kinase reverses the inhibitory effect of ceramide on Na+-ATPase Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
 Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.2.2.3 phosphoprotein Na+-ATPase is inhibited by reversible phosphorylation through protein kinase A and protein kinase Czeta Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Sus scrofa
-
7.2.2.3 renal tubule basolateral membranes of kidney proximal tubule cells Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.3 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7.4
-
 assay at Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.3 0.0001
-
 pH 7.4, 37°C Sus scrofa ceramide

General Information

EC Number General Information Comment Organism
7.2.2.3 additional information Cer acts as a potent physiological modulator of the Na+-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta Sus scrofa
7.2.2.3 physiological function the Na+-ATPase is involved in Na+ reabsorption in the kidney. Ouabain-insensitive Na+-ATPase is considered the fine tuner of cytosolic Na+, the selective key roles of ceramide under Na+-induced osmotic stress Sus scrofa