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Literature summary extracted from

  • Lara, L.S.; Vives, D.; Correa, J.S.; Cardozo, F.P.; Marques-Fernades, M.F.; Lopes, A.G.; Caruso-Neves, C.
    PKA-mediated effect of MAS receptor in counteracting angiotensin II-stimulated renal Na+-ATPase (2010), Arch. Biochem. Biophys., 496, 117-122.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.3 angiotensin II stimulates the renal Na+-ATPase, reversed by Ang-(1-7) via MAS and the A779-sensitive MAS receptor in a Gs/PKA pathway, molecular mechanism, overview Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 Ouabain
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
 Sus scrofa 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.3 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Sus scrofa
-
7.2.2.3 renal tubule basolateral membranes of kidney proximal tubule cells Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.3 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7
-
 assay at Sus scrofa

General Information

EC Number General Information Comment Organism
7.2.2.3 metabolism important regulatory role of Ang-(1-7) in the action of angiotensin II on the Na+-ATPase activity of proximal tubule cells by activation of MAS receptor. The MAS receptor plays an important role as a regulator of the effects mediated by AT1 receptor on proximal tubule sodium reabsorption and renal sodium excretion, overview Sus scrofa