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Literature summary extracted from

  • Assaife-Lopes, N.; Wengert, M.; de Sa Pinheiro, A.A.; Leao-Ferreira, L.R.; Caruso-Neves, C.
    Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway (2009), Arch. Biochem. Biophys., 489, 76-81.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 adenosine inhibits independently of the A3 receptor Sus scrofa
7.2.2.3 Furosemide a Na+-ATPase specific inhibitor Sus scrofa
7.2.2.3 Inosine inhibits independently of the A3 receptor Sus scrofa
7.2.2.3 additional information adenine induces inhibition of Na+-ATPase activity Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
 Sus scrofa 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.3 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.3 native enzyme from kidney cortex and basolateral membranes of proximal renal tubule cells Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Sus scrofa
-
7.2.2.3 renal tubule basolateral membranes of kidney proximal tubule cells Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 renal Na+-ATPase
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7
-
 assay at Sus scrofa

General Information

EC Number General Information Comment Organism
7.2.2.3 additional information inosine-induced inhibition of Na+-ATPase activity could be involved in the increased renal sodium excretion during short periods of ischemia Sus scrofa