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Literature summary extracted from

  • Zhao, Y.; Seefeldt, T.; Chen, W.; Wang, X.; Matthees, D.; Hu, Y.; Guan, X.
    Effects of glutathione reductase inhibition on cellular thiol redox state and related systems (2009), Arch. Biochem. Biophys., 485, 56-62.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 2-acetylamino-3-[4-(2-acetylamino-2-carboxy-ethylsulfanylthio carbonylamino)phenylthiocarbamoylsulfanyl]propionic acid irreversible and selective glutathione reductase inhibitor, almost complete inhibition at 0.1 mM for 1 h, thereafter, the enzyme activity starts to return and reaches 63% of the control at the end of 8 h Chlorocebus aethiops

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Chlorocebus aethiops
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 CV-1 cell
-
 Chlorocebus aethiops
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Chlorocebus aethiops glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Chlorocebus aethiops

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Chlorocebus aethiops
1.8.1.7 NADPH
-
 Chlorocebus aethiops

General Information

EC Number General Information Comment Organism
1.8.1.7 malfunction in addition to a decrease in GSH and increase in GSSG, inhibition of glutathione reductase increases the ratios of NADH/NAD+ and NADPH/NADP+. Significant protein glutathionylation is observed. However, the inhibition does not affect the formation of reactive oxygen species or expression of antioxidant defense enzyme systems (glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase) Chlorocebus aethiops