Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, R.J.; Chung, T.Y.; Li, F.Y.; Yang, W.H.; Jinn, T.R.; Tzen, J.T.
    Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase (2010), Acta Pharmacol. Sin., 31, 696-702.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 astragaloside III from dried roots of Astragalus membraneceus or var. mongholicus Sus scrofa
7.2.2.13 bufalin from dried venom of Bufo gargarizans or Bufo bufo melanostictus Sus scrofa
7.2.2.13 cholic acid from dried bile of Ursus arctos or Selenarctos thibetanus Sus scrofa
7.2.2.13 ginsenoside Rh2 from dried roots of Panax ginseng or Panax notoginseng Sus scrofa
7.2.2.13 glycyrrhizin from roots of Glycyrrhiza uralensis , Glycyrrhiza inflata, or Glycyrrhiza glabra Sus scrofa
7.2.2.13 jujuboside B from mature seeds of Ziziphus jujube var. spinosa Sus scrofa
7.2.2.13 additional information molecular docking and modelling, and inhibitory potencies of steroid-like compounds from Chinese medicinal products, used for promoting the blood circulation, with Na+,K+-ATPase, overview Sus scrofa
7.2.2.13 oleanolic acid from whole plant of Prunella vulgaris with dried flowers Sus scrofa
7.2.2.13 Ouabain
-
 Sus scrofa
7.2.2.13 polygalacic acid from dried roots of Platycodon grandiflorum Sus scrofa
7.2.2.13 saikosaponin A from dried roots of Bupleurum chinense or Bupleurum scorzonerifolium Sus scrofa
7.2.2.13 sarsasapogenin from dried roots of Anemarrhena asphodeloides Sus scrofa
7.2.2.13 ursolic acid from whole plant of Prunella vulgaris with dried flowers Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.13 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out Sus scrofa
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 brain cerebral cortex Sus scrofa
-
7.2.2.13 commercial preparation
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Sus scrofa ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+/K+ -ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.13 22
-
 assay at room temperature Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.13 7.8
-
 assay at Sus scrofa