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Literature summary extracted from

  • Wei, J.F.; Wei, X.L.; Mo, Y.Z.; He, S.H.
    Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2 (2010), Toxicon, 55, 888-896.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 cyproheptadine at a dose of 5 mg inhibits 82% promutoxin elicited microvascular leakage Protobothrops mucrosquamatus
3.1.1.4 ginkgolide B ginkgolide B at a dose of 5 mg inhibits 31% microvascular leakage induced by promutoxin when they are coinjected Protobothrops mucrosquamatus
3.1.1.4 heparin at a dose of 5 mg inhibits 49% promutoxin elicited microvascular leakage. At 10 and 100 microg/ml diminishes promutoxin-induced histamine release from lung mast cells by 56% and 53%, has little effect on promutoxin-induced histamine release from colon mast cells. At a concentration of 100 microg/ml, heparin inhibits promutoxin-induced histamine release from tonsil mast cells Protobothrops mucrosquamatus
3.1.1.4 additional information promutoxin induced histamine release from colon, lung and tonsil mast cells is inhibited by up to 89%, 99% and 90%, respectively when cells are pretreated with metabolic inhibitors for 40 min. Quinacrine at the dose of 5 mg has little effect on promutoxin provoked microvascular leakage in rat skin Protobothrops mucrosquamatus
3.1.1.4 pertussis toxin inhibits dramatically promutoxin-induced histamine release from colon mast cells, but has less effect on promutoxin-induced histamine release from lung cells Protobothrops mucrosquamatus
3.1.1.4 terfenadine at a dose of 5 mg inhibits 67% promutoxin elicited microvascular leakage Protobothrops mucrosquamatus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Protobothrops mucrosquamatus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 gel filtration, at least 98% pure Protobothrops mucrosquamatus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Protobothrops mucrosquamatus
-

Storage Stability

EC Number Storage Stability Organism
3.1.1.4 -20°C Protobothrops mucrosquamatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 egg yolk + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.1.1.4 phosphatidylcholine + H2O
-
 Protobothrops mucrosquamatus 1-acylglycerophosphocholine + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 Arg49 phospholipase A2
-
 Protobothrops mucrosquamatus
3.1.1.4 promutoxin
-
 Protobothrops mucrosquamatus
3.1.1.4 R49 PLA2
-
 Protobothrops mucrosquamatus

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function promutoxin can provoke microvascular leakage in the skin of rats and induce a dose-dependent release of histamine from colon, lung and tonsil from human mast cells in vitro Protobothrops mucrosquamatus