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Literature summary extracted from

  • Comellas, G.; Kaczmarska, Z.; Tarragó, T.; Teixidó, M.; Giralt, E.
    Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates (2009), PLoS ONE, 4, e6222.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 Z-proline prolinal
-
Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.26 more than 90% purity Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 brain
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 AbzGFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa AbzGFGP + FGF(p-NO2)A-NH2
-
?
3.4.21.26 H-(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-Abz-GFGP-OH + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-Abz-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-F(p-NO2)GFGP-OH + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-HMBA-PEGA
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-NH2
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-HMBA-PEGA
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-NH2
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-HMBA-PEGA + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-HMBA-PEGA
-
?
3.4.21.26 H-F(p-NO2)GFGPFGK(Abz)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa H-F(p-NO2)GFGP + FGK(Abz)A-NH2
-
?
3.4.21.26 H-FGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 H-O2Oc-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 PEGA(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 PEGA-K(ABz)-GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?
3.4.21.26 PEGA-O2Oc-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 prolyl oligopeptidase
-
Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.26 37
-
assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.26 8
-
assay at Sus scrofa

General Information

EC Number General Information Comment Organism
3.4.21.26 malfunction enzyme associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders Sus scrofa