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Literature summary extracted from

  • Esteves, A.R.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.
    Dysfunctional mitochondria uphold calpain activation: contribution to Parkinsons disease pathology (2010), Neurobiol. Dis., 37, 723-730.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.52 medicine calpain and calpain inhibition is a therapeutic tool in Parkinson’s disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 MDL-28710 complete inhibition at 100 nM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.52 mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ dependent on, dysfunctional mitochondria increase cytosolic calcium, thereby inducing calpain activation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 NT2-Rho0 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O
-
 Homo sapiens acetyl-LLY + 7-amino-4-fluoromethylcoumarin
-
 ?
3.4.22.52 alpha-synuclein + H2O
-
 Homo sapiens 145000 DA fragment + 150 Da fragment + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain 1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.22.52 Homo sapiens compared to control cybrids, Parkonsin’s disease cybrids reveal a significant increase in calpain activity up

General Information

EC Number General Information Comment Organism
3.4.22.52 malfunction calpain-1 overactivation in mitochondrial-deficient cells promotes caspase-3 activation, calpain inhibition decreases alpha-synuclein oligomerization Homo sapiens