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Literature summary extracted from

  • Webb, L.M.; Arnholt, A.T.; Venable, M.E.
    Phospholipase D modulation by ceramide in senescence (2010), Mol. Cell. Biochem., 337, 153-158.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 GTP-binding proteins the PLD1 isoform can be activated by GTP-binding proteins, PKC, and tyrosine kinases. Synergistic activation of PLD1 with combinations of ARF and Rho, Rho and PKC, and ARF and PKC. Isozyme PLD2 remains unaffected by these activators Homo sapiens
3.1.4.4 phosphatidylinositol-4,5-bisphosphate required for PLD2 activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 ceramide inhibits PLD at the catalytic subunit by competing with phosphatidylinositol-4,5-bisphosphate. Ceramide levels are increased coincidentally with reduced PLD activity in senescent cells. Treatment of cells with ceramide results in a dose-dependent decrease in PLD activity and diacylglycerol accumulation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 membrane PLD is predominantly a membrane-bound enzyme Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 endothelial cell HUVECs Homo sapiens
-
3.1.4.4 additional information senescent cells show reduced levels of PLD activity. Ceramide levels are increased coincidentally with reduced PLD activity in senescent cells Homo sapiens
-
3.1.4.4 umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.4.4 Homo sapiens PLD is suppressed in endothelial cell senescence down

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function PLD may play a role in mitosis through the production of diacylglycerol, phosphatidic acid, and lysophosphatidic acid Homo sapiens