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Literature summary extracted from

  • Goettle, M.; Geduhn, J.; Koenig, B.; Gille, A.; Hoecherl, K.; Seifert, R.
    Characterization of mouse heart adenylyl cyclase (2009), J. Pharmacol. Exp. Ther., 329, 1156-1165.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 dopamine about 2fold activation by 0.1 mM Mus musculus
4.6.1.1 epinephrine about 2fold activation by 0.1 mM Mus musculus
4.6.1.1 forskolin forskolin increases basal AC activity in Sf9 cell membranes expressing isoforms AC1 and AC2 by about 2-5fold, forskolin activates ACs in the order of potency AC1>AC5>mouse heart AC >AC2 Mus musculus
4.6.1.1 GTPgammaS in the presence of Mg2+, GTPgammaS increases adenylyl cyclase activity 4fold, with an EC50 value of 80 nM Mus musculus
4.6.1.1 isoproterenol in the presence of GTP (0.01 mM), isoproterenol increases adenylyl cyclase activity approximately 2fold, with an EC50 value of 12 nM Mus musculus
4.6.1.1 additional information no activation by histamine, glucagon, neuropeptide Y, and serotonin Mus musculus
4.6.1.1 norepinephrine about 2fold activation by 0.1 mM Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 expressed in Sf9 insect cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 2'(3')-O-(N-methylanthraniloyl)-ITP most potent inhibitor of heart adenylyl cyclase and recombinant AC5 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane
-
 Mus musculus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 120000 140000 SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 heart isoforms AC3, AC5, and AC7 are detected in heart, AC5 is an important adenylyl cyclase isoform in heart Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC1 isoform Mus musculus
4.6.1.1 AC2 isoform Mus musculus
4.6.1.1 AC3 isoform Mus musculus
4.6.1.1 AC5 isoform Mus musculus
4.6.1.1 AC7 isoform Mus musculus
4.6.1.1 type 5 adenylyl cyclase
-
 Mus musculus