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Literature summary extracted from
- Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis (2010), J. Neuroinflammation, 7, 23.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | additional information | decrease in enzyme activity in plasma of relapsing remitting multiple sclerose patients | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | Z-Pro-prolinal | - |
Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Homo sapiens | - |
- |
- |
| 3.4.21.26 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | partial, ion exchange chromatography | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | - |
Sus scrofa | - |
| 3.4.21.26 | plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | Z-Gly-Pro-7-amido-4-methylcoumarin | assay at pH 7.0, 30°C | Sus scrofa | Z-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.21.26 | Z-Gly-Pro-7-amido-4-methylcoumarin + H2O | assay at pH 7.0, 30°C | Homo sapiens | z-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Sus scrofa |
| 3.4.21.26 | prolyl oligopeptidase | - |
Homo sapiens |
| 3.4.21.26 | prolyl oligopeptidase | - |
Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 30 | - |
assay at | Homo sapiens |
| 3.4.21.26 | 30 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 7 | - |
assay at | Homo sapiens |
| 3.4.21.26 | 7 | - |
assay at | Sus scrofa |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | physiological function | implicated in neurodegeneration and in modulation of the inflammatory response | Homo sapiens |
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