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Literature summary extracted from

  • Hambsch, B.; Chen, B.G.; Brenndoerfer, J.; Meyer, M.; Avrabos, C.; Maccarrone, G.; Liu, R.H.; Eder, M.; Turck, C.W.; Landgraf, R.
    Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain (2010), J. Neurochem., 113, 1240-1251.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Mus musculus (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 Glo1
-
 Mus musculus
4.4.1.5 glyoxalase I
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Mus musculus

Expression

EC Number Organism Comment Expression
4.4.1.5 Mus musculus methylglyoxal-mediated anxiolysis involves elevated expression of glyoxalase 1 in the brain, methylglyoxal treatment increases expression of GLO1 only in CD1 mice that do not have extra copies of GLO1. GLO1 expression is ubiquitously elevated in low-anxiety-related behavior-phenotype brain. Methylglyoxal injections into the lateral ventricle of hyper-anxious-related behavior-phenotype mice enhance GLO1 expression up