Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koch, T.; Seifert, A.; Wu, D.F.; Rankovic, M.; Kraus, J.; Boerner, C.; Brandenburg, L.O.; Schroeder, H.; Hoellt, V.
    mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2 (2009), J. Neurochem., 110, 1288-1296.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 beta-endorphin opioid receptor-mediated activation Homo sapiens
3.1.4.4 additional information [D-Ala2,Me Phe4,Glyol5]enkephalin and beta-endorphin strongly induce PLD2 activation, whereas the non-endocytotic drugs morphine and buprenorphine do not activate PLD2 Homo sapiens
3.1.4.4 phorbol-12-myristate-13-acetate induces PLD2 activation Homo sapiens
3.1.4.4 [D-Ala2,Me Phe4,Glyol5]enkephalin opioid receptor-mediated activation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information siRNA-mediated reduction of endogenous PLD2 expression results in a nearly complete inhibition of the opioid-induced H2O2 production in Rattus norvegicus mu-opioid receptor MOPr-expressing HEK293 cells, while in control cells it has no effect on [D-Ala2,Me Phe4,Glyol5]enkephalin and beta-endorphin effects on the DCFDA fluorescence Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 sphinganine does not alter basal PLD2 activity, but inhibits PLD2 activation induced by [D-Ala2,Me Phe4,Glyol5]enkephalin and beta-endorphin, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozyme PLD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information the enzyme also performs transphosphatidylation transferring phosphatidic acid to a primary alcohol Homo sapiens ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 phospholipase D2
-
 Homo sapiens
3.1.4.4 PLD2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.4 37
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function essential role of PLD2 activity in the opioid-mediated induction of reactive oxygen species synthesis Homo sapiens