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Literature summary extracted from

  • Hernando, V.; Inserte, J.; Sartorio, C.L.; Parra, V.M.; Poncelas-Nozal, M.; Garcia-Dorado, D.
    Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion (2010), J. Mol. Cell. Cardiol., 49, 271-279.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.53 medicine m-calpain inhibition at the time of reperfusion is a potentially useful strategy to limit infarct size Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.53 calpastatin
-
 Rattus norvegicus
3.4.22.53 MDL-28170
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.53 membrane
-
 Rattus norvegicus 16020
-
3.4.22.53 membrane in isolated rat hearts, ischemia induces a time-dependent translocation of m-calpain to the membrane that is not associated with calpain activation Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.53 Ca2+ Ca2+ induces calpain translocation to the membrane during ischemia Rattus norvegicus
3.4.22.53 Ca2+ Ca2+-induced calpain translocation to the membrane during ischemia is independent of its activation Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.53 70000
-
 SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.53 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.53 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.53 alpha-fodrin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.53 m-calpain
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.22.53 Rattus norvegicus calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin up
3.4.22.53 Rattus norvegicus m-calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin up

General Information

EC Number General Information Comment Organism
3.4.22.53 physiological function m-calpain translocates during ischemia and activates at reperfusion in isolated rat hearts Rattus norvegicus