EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.3.16 | medicine | protein phosphatase inhibitor-1-based therapeutic interventions may ameliorate cardiac dysfunction and remodeling in the failing heart, mechanism and mode of action, overview | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.16 | protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Cavia porcellus | |
3.1.3.16 | protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Homo sapiens | |
3.1.3.16 | protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Mus musculus | |
3.1.3.16 | protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.3.16 | sarcoplasmic reticulum | - |
Cavia porcellus | 16529 | - |
3.1.3.16 | sarcoplasmic reticulum | - |
Mus musculus | 16529 | - |
3.1.3.16 | sarcoplasmic reticulum | - |
Homo sapiens | 16529 | - |
3.1.3.16 | sarcoplasmic reticulum | - |
Rattus norvegicus | 16529 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.16 | Ca2+ | dependent on | Cavia porcellus | |
3.1.3.16 | Ca2+ | dependent on | Mus musculus | |
3.1.3.16 | Ca2+ | dependent on | Homo sapiens | |
3.1.3.16 | Ca2+ | dependent on | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.16 | phosphorylated lamban + H2O | Cavia porcellus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | Mus musculus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | Homo sapiens | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | Rattus norvegicus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.16 | Cavia porcellus | - |
- |
- |
3.1.3.16 | Homo sapiens | - |
- |
- |
3.1.3.16 | Mus musculus | - |
- |
- |
3.1.3.16 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.16 | cardiomyocyte | - |
Homo sapiens | - |
3.1.3.16 | heart | - |
Cavia porcellus | - |
3.1.3.16 | heart | - |
Mus musculus | - |
3.1.3.16 | heart | - |
Homo sapiens | - |
3.1.3.16 | heart | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.16 | phosphorylated lamban + H2O | - |
Cavia porcellus | lamban + phosphate | - |
? | |
3.1.3.16 | phosphorylated lamban + H2O | - |
Mus musculus | lamban + phosphate | - |
? | |
3.1.3.16 | phosphorylated lamban + H2O | - |
Homo sapiens | lamban + phosphate | - |
? | |
3.1.3.16 | phosphorylated lamban + H2O | - |
Rattus norvegicus | lamban + phosphate | - |
? | |
3.1.3.16 | phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Cavia porcellus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Mus musculus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Homo sapiens | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
3.1.3.16 | phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Rattus norvegicus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.16 | PP1 | - |
Cavia porcellus |
3.1.3.16 | PP1 | - |
Mus musculus |
3.1.3.16 | PP1 | - |
Homo sapiens |
3.1.3.16 | PP1 | - |
Rattus norvegicus |
3.1.3.16 | PP2A | - |
Homo sapiens |
3.1.3.16 | protein phosphatase-1 | - |
Cavia porcellus |
3.1.3.16 | protein phosphatase-1 | - |
Mus musculus |
3.1.3.16 | protein phosphatase-1 | - |
Homo sapiens |
3.1.3.16 | protein phosphatase-1 | - |
Rattus norvegicus |
3.1.3.16 | type 1 protein phosphatase | - |
Cavia porcellus |
3.1.3.16 | type 1 protein phosphatase | - |
Mus musculus |
3.1.3.16 | type 1 protein phosphatase | - |
Homo sapiens |
3.1.3.16 | type 1 protein phosphatase | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.16 | malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Cavia porcellus |
3.1.3.16 | malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Mus musculus |
3.1.3.16 | malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Homo sapiens |
3.1.3.16 | malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Rattus norvegicus |
3.1.3.16 | physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Cavia porcellus |
3.1.3.16 | physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Mus musculus |
3.1.3.16 | physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Homo sapiens |
3.1.3.16 | physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Rattus norvegicus |