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Literature summary extracted from
- Inhibitors of prolyl oligopeptidases for the therapy of human diseases: Defining diseases and inhibitors (2010), J. Med. Chem., 53, 3423-3438.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | medicine | potential target in cognitive function, memory and neurodegenerative disorders | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | (2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbaldehyde | - |
Canis lupus familiaris |  |
| 3.4.21.26 | (2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbonitrile | - |
Canis lupus familiaris | |
| 3.4.21.26 | (2S)-1-[1-(3-[[(2S)-2-(cyclopentylcarbonyl)pyrrolidin-1-yl]carbonyl]benzoyl)-L-prolyl]pyrrolidine-2-carbonitrile | - |
Sus scrofa | |
| 3.4.21.26 | (2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbaldehyde | - |
Sus scrofa | |
| 3.4.21.26 | (2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile | - |
Sus scrofa | |
| 3.4.21.26 | (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one | - |
Homo sapiens | |
| 3.4.21.26 | 1,2-oxazolidin-2-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | 1-(cyclopent-1-en-1-ylcarbonyl)-N-(2-phenylethyl)-L-prolinamide | - |
Sus scrofa | |
| 3.4.21.26 | 1-[(2R,5S)-2-(propan-2-yl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(pyridin-3-yl)butan-1-one | - |
Sus scrofa | |
| 3.4.21.26 | 1-[(2R,5S)-2-tert-butyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one | - |
Sus scrofa | |
| 3.4.21.26 | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone | - |
Canis lupus familiaris | |
| 3.4.21.26 | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone | - |
Canis lupus familiaris | |
| 3.4.21.26 | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(thiophen-2-yl)butan-1-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]octan-1-one | - |
Rattus norvegicus | |
| 3.4.21.26 | 1-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-3-phenylquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
| 3.4.21.26 | 1-[[(2S)-1-(4-phenylbutanoyl)pyrrolidin-2-yl]carbonyl]pyrrolidin-2-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 2,3-dihydro-1H-inden-2-yl[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methanone | - |
Canis lupus familiaris | |
| 3.4.21.26 | 2,3-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | 2,5-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | 2-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethanone | - |
Canis lupus familiaris | |
| 3.4.21.26 | 2-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-1H-isoindole-1,3(2H)-dione | - |
Rattus norvegicus | |
| 3.4.21.26 | 2-[2-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-oxoethyl]-1H-isoindole-1,3(2H)-dione | - |
Rattus norvegicus | |
| 3.4.21.26 | 3-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-1-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide | - |
Sus scrofa | |
| 3.4.21.26 | 3-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-5,5-diphenylimidazolidine-2,4-dione | - |
Rattus norvegicus | |
| 3.4.21.26 | 4-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-1-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide | - |
Homo sapiens | |
| 3.4.21.26 | 4-phenyl-1-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]butan-1-one | - |
Bos taurus | |
| 3.4.21.26 | 4-phenyl-1-[(2S)-2-[[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidin-1-yl]butan-1-one | - |
Sus scrofa | |
| 3.4.21.26 | 4-phenyl-1-[(3S)-3-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]butan-1-one | - |
Homo sapiens | |
| 3.4.21.26 | 4-phenyl-1-[(4R)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 4-phenyl-1-[(4S)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one | - |
Canis lupus familiaris | |
| 3.4.21.26 | 4-phenyl-1-[2-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one | - |
Sus scrofa | |
| 3.4.21.26 | 4-phenyl-1-[5-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one | - |
Sus scrofa | |
| 3.4.21.26 | 9H-fluoren-9-ylmethyl [(2S)-5-carbamimidamido-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate | - |
Mus musculus | |
| 3.4.21.26 | Baicalin | - |
Homo sapiens | |
| 3.4.21.26 | benzyl (1S,2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]cyclohexanecarboxylate | - |
Mus musculus | |
| 3.4.21.26 | benzyl (2S)-2-(1,3-oxazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-[(1-oxido-1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Homo sapiens | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-2,3-dihydro-1H-indole-1-carboxylate | - |
Mus musculus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-5-oxopyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Bos taurus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Elizabethkingia meningoseptica | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Mus musculus | |
| 3.4.21.26 | benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Oryctolagus cuniculus | |
| 3.4.21.26 | benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate | - |
Homo sapiens | |
| 3.4.21.26 | benzyl [2-[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]carbamate | - |
Bos taurus | |
| 3.4.21.26 | Berberine | - |
Homo sapiens | |
| 3.4.21.26 | JTP-4819 | - |
Rattus norvegicus | |
| 3.4.21.26 | N-[(2S)-1-[(2S)-2-formylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide | - |
Bos taurus | |
| 3.4.21.26 | N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-2-yl]-3-phenoxybenzamide | - |
Sus scrofa | |
| 3.4.21.26 | ONO-1603 | - |
Rattus norvegicus | |
| 3.4.21.26 | SUAM-1221 | - |
Bos taurus | |
| 3.4.21.26 | SUAM-1221 | - |
Canis lupus familiaris | |
| 3.4.21.26 | SUAM-1221 | - |
Mus musculus | |
| 3.4.21.26 | SUAM-1221 | - |
Rattus norvegicus | |
| 3.4.21.26 | SUAM-1221 | - |
Sus scrofa | |
| 3.4.21.26 | tert-butyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate | - |
Sus scrofa | |
| 3.4.21.26 | tert-butyl [(2S)-3-methyl-1-(1,3-thiazolidin-3-yl)-1-thioxobutan-2-yl]carbamate | - |
Homo sapiens | |
| 3.4.21.26 | UAMC-00021 | - |
Sus scrofa | |
| 3.4.21.26 | Y-29794 | - |
Rattus norvegicus | |
| 3.4.21.26 | ZTTA | - |
Rattus norvegicus | |
| 3.4.21.26 | [(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | - |
Homo sapiens | |
| 3.4.21.26 | [(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1H-pyrrol-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | [(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(pyrrolidin-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | [(1R,2R)-2-phenylcyclopropyl][(3S)-3-(pyrrolidin-1-ylcarbonyl)-2-azabicyclo[2.2.2]oct-2-yl]methanone | - |
Rattus norvegicus | |
| 3.4.21.26 | [(2R)-1-[N-(2,5-dichlorobenzoyl)glycyl]pyrrolidin-2-yl]boronic acid | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | angiotensin I + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Bos taurus | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Oryctolagus cuniculus | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Canis lupus familiaris | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | Sus scrofa | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Bos taurus | - |
- |
- |
| 3.4.21.26 | Canis lupus familiaris | - |
- |
- |
| 3.4.21.26 | Elizabethkingia meningoseptica | - |
- |
- |
| 3.4.21.26 | Homo sapiens | - |
- |
- |
| 3.4.21.26 | Mus musculus | - |
- |
- |
| 3.4.21.26 | Oryctolagus cuniculus | - |
- |
- |
| 3.4.21.26 | Rattus norvegicus | - |
- |
- |
| 3.4.21.26 | Sus scrofa | P23687 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | high expression | Mus musculus | - |
| 3.4.21.26 | brain | high expression | Homo sapiens | - |
| 3.4.21.26 | brain | high expression | Rattus norvegicus | - |
| 3.4.21.26 | brain | high expression | Bos taurus | - |
| 3.4.21.26 | brain | high expression | Oryctolagus cuniculus | - |
| 3.4.21.26 | brain | high expression | Canis lupus familiaris | - |
| 3.4.21.26 | brain | high expression | Sus scrofa | - |
| 3.4.21.26 | brain cortex cell line | - |
Rattus norvegicus | - |
| 3.4.21.26 | kidney | - |
Sus scrofa | - |
| 3.4.21.26 | peripheral blood mononuclear cell | - |
Homo sapiens | - |
| 3.4.21.26 | placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | angiotensin I + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | bradykinin potentiating peptide + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | Luliberin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | melanotropin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | oxytocin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | thyroliberin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | tuftsin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | Vasopressin + H2O | - |
Sus scrofa | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Mus musculus |
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Rattus norvegicus |
| 3.4.21.26 | POP | - |
Bos taurus |
| 3.4.21.26 | POP | - |
Oryctolagus cuniculus |
| 3.4.21.26 | POP | - |
Canis lupus familiaris |
| 3.4.21.26 | POP | - |
Elizabethkingia meningoseptica |
| 3.4.21.26 | POP | - |
Sus scrofa |
| 3.4.21.26 | prolyl oligopeptidase | - |
Mus musculus |
| 3.4.21.26 | prolyl oligopeptidase | - |
Homo sapiens |
| 3.4.21.26 | prolyl oligopeptidase | - |
Rattus norvegicus |
| 3.4.21.26 | prolyl oligopeptidase | - |
Bos taurus |
| 3.4.21.26 | prolyl oligopeptidase | - |
Oryctolagus cuniculus |
| 3.4.21.26 | prolyl oligopeptidase | - |
Canis lupus familiaris |
| 3.4.21.26 | prolyl oligopeptidase | - |
Elizabethkingia meningoseptica |
| 3.4.21.26 | prolyl oligopeptidase | - |
Sus scrofa |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | additional information | - |
benzyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate | brain, value between 0.0021 and 0.0024 mM | Bos taurus | |
| 3.4.21.26 | additional information | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | brain, value between 0.21 and 5 nM | Bos taurus | |
| 3.4.21.26 | additional information | - |
benzyl (2S)-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate | brain, value between 39 and 110 nM | Bos taurus | |
| 3.4.21.26 | 0.00000035 | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | brain | Mus musculus | |
| 3.4.21.26 | 0.00000036 | - |
(2S)-1-[1-(3-[[(2S)-2-(cyclopentylcarbonyl)pyrrolidin-1-yl]carbonyl]benzoyl)-L-prolyl]pyrrolidine-2-carbonitrile | brain | Sus scrofa | |
| 3.4.21.26 | 0.0000005 | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | - |
Elizabethkingia meningoseptica | |
| 3.4.21.26 | 0.00000095 | - |
Y-29794 | rat cortex | Rattus norvegicus | |
| 3.4.21.26 | 0.0000015 | - |
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | - |
Homo sapiens | |
| 3.4.21.26 | 0.0000022 | - |
[(2R)-1-[N-(2,5-dichlorobenzoyl)glycyl]pyrrolidin-2-yl]boronic acid | - |
Homo sapiens | |
| 3.4.21.26 | 0.0000024 | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-2,3-dihydro-1H-indole-1-carboxylate | brain | Mus musculus | |
| 3.4.21.26 | 0.000003 | - |
benzyl (1S,2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]cyclohexanecarboxylate | brain | Mus musculus | |
| 3.4.21.26 | 0.0000034 | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-5-oxopyrrolidine-1-carboxylate | brain | Bos taurus | |
| 3.4.21.26 | 0.000012 | - |
ONO-1603 | rat cortex | Rattus norvegicus | |
| 3.4.21.26 | 0.000014 | - |
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | brain | Oryctolagus cuniculus | |
| 3.4.21.26 | 0.000033 | - |
9H-fluoren-9-ylmethyl [(2S)-5-carbamimidamido-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate | brain | Mus musculus | |
| 3.4.21.26 | 0.0002 | - |
benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate | human brain | Homo sapiens | |
| 3.4.21.26 | 0.00161 | - |
benzyl (2S)-2-[(1-oxido-1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate | brain | Bos taurus | |
| 3.4.21.26 | 0.0029 | - |
benzyl (2S)-2-(1,3-oxazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate | brain | Bos taurus | |
| 3.4.21.26 | 0.0029 | - |
ZTTA | rat brain | Rattus norvegicus | |
| 3.4.21.26 | 0.00554 | - |
tert-butyl [(2S)-3-methyl-1-(1,3-thiazolidin-3-yl)-1-thioxobutan-2-yl]carbamate | human placenta | Homo sapiens | |
| 3.4.21.26 | 0.042 | - |
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | brain | Bos taurus | |
| 3.4.21.26 | 0.07 | - |
benzyl [2-[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]carbamate | brain | Bos taurus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.000000023 | - |
- |
Sus scrofa | (2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile | |
| 3.4.21.26 | 0.00000045 | - |
brain | Canis lupus familiaris | (2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbaldehyde | |
| 3.4.21.26 | 0.00000081 | - |
rat brain | Rattus norvegicus | 2-[2-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-oxoethyl]-1H-isoindole-1,3(2H)-dione | |
| 3.4.21.26 | 0.00000083 | - |
rat brain | Rattus norvegicus | JTP-4819 | |
| 3.4.21.26 | 0.00000088 | - |
rat brain | Rattus norvegicus | 1-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-3-phenylquinoxalin-2(1H)-one | |
| 3.4.21.26 | 0.00000105 | - |
kidney | Sus scrofa | N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-2-yl]-3-phenoxybenzamide | |
| 3.4.21.26 | 0.00000107 | - |
kidney | Sus scrofa | 3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide | |
| 3.4.21.26 | 0.0000012 | - |
brain | Sus scrofa | 1-[(2R,5S)-2-tert-butyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one | |
| 3.4.21.26 | 0.0000012 | - |
brain | Canis lupus familiaris | (2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbonitrile | |
| 3.4.21.26 | 0.0000012 | - |
rat cortex | Rattus norvegicus | [(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(pyrrolidin-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | |
| 3.4.21.26 | 0.0000013 | - |
brain | Sus scrofa | 4-phenyl-1-[5-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one | |
| 3.4.21.26 | 0.0000016 | - |
- |
Sus scrofa | UAMC-00021 | |
| 3.4.21.26 | 0.000002 | - |
rat cortex | Rattus norvegicus | 1,2-oxazolidin-2-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | |
| 3.4.21.26 | 0.0000021 | - |
brain | Sus scrofa | 1-[(2R,5S)-2-(propan-2-yl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(pyridin-3-yl)butan-1-one | |
| 3.4.21.26 | 0.0000022 | - |
brain | Sus scrofa | SUAM-1221 | |
| 3.4.21.26 | 0.0000023 | - |
rat cortex | Rattus norvegicus | [(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1H-pyrrol-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone | |
| 3.4.21.26 | 0.0000024 | - |
rat cortex | Rattus norvegicus | 2,5-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | |
| 3.4.21.26 | 0.0000027 | - |
rat cortex | Rattus norvegicus | 2,3-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone | |
| 3.4.21.26 | 0.000003 | - |
rat brain | Rattus norvegicus | 2-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-1H-isoindole-1,3(2H)-dione | |
| 3.4.21.26 | 0.0000042 | - |
brain | Bos taurus | N-[(2S)-1-[(2S)-2-formylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide | |
| 3.4.21.26 | 0.0000047 | - |
brain | Mus musculus | SUAM-1221 | |
| 3.4.21.26 | 0.000005 | - |
kidney | Sus scrofa | 4-phenyl-1-[(2S)-2-[[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidin-1-yl]butan-1-one | |
| 3.4.21.26 | 0.000005 | - |
rat cortex | Rattus norvegicus | [(1R,2R)-2-phenylcyclopropyl][(3S)-3-(pyrrolidin-1-ylcarbonyl)-2-azabicyclo[2.2.2]oct-2-yl]methanone | |
| 3.4.21.26 | 0.0000054 | - |
brain | Canis lupus familiaris | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone | |
| 3.4.21.26 | 0.0000072 | - |
rat brain | Rattus norvegicus | SUAM-1221 | |
| 3.4.21.26 | 0.0000087 | - |
kidney | Sus scrofa | (2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbaldehyde | |
| 3.4.21.26 | 0.00001 | - |
brain | Canis lupus familiaris | 2-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethanone | |
| 3.4.21.26 | 0.000012 | - |
- |
Homo sapiens | (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one | |
| 3.4.21.26 | 0.00002 | - |
rat brain | Rattus norvegicus | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]octan-1-one | |
| 3.4.21.26 | 0.000021 | - |
brain | Canis lupus familiaris | 4-phenyl-1-[(4R)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one | |
| 3.4.21.26 | 0.000029 | - |
brain | Sus scrofa | tert-butyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate | |
| 3.4.21.26 | 0.000034 | - |
brain | Canis lupus familiaris | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(thiophen-2-yl)butan-1-one | |
| 3.4.21.26 | 0.000036 | - |
brain | Canis lupus familiaris | 3-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-1-one | |
| 3.4.21.26 | 0.000041 | - |
rat brain | Rattus norvegicus | 3-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-5,5-diphenylimidazolidine-2,4-dione | |
| 3.4.21.26 | 0.000054 | - |
brain | Canis lupus familiaris | 1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone | |
| 3.4.21.26 | 0.00006 | - |
brain | Canis lupus familiaris | 4-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-1-one | |
| 3.4.21.26 | 0.000076 | - |
brain | Canis lupus familiaris | SUAM-1221 | |
| 3.4.21.26 | 0.00011 | - |
brain | Sus scrofa | 1-(cyclopent-1-en-1-ylcarbonyl)-N-(2-phenylethyl)-L-prolinamide | |
| 3.4.21.26 | 0.00023 | - |
brain | Sus scrofa | 4-phenyl-1-[2-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one | |
| 3.4.21.26 | 0.00052 | - |
brain | Canis lupus familiaris | 2,3-dihydro-1H-inden-2-yl[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methanone | |
| 3.4.21.26 | 0.00055 | - |
- |
Homo sapiens | 4-phenyl-1-[(3S)-3-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]butan-1-one | |
| 3.4.21.26 | 0.0021 | - |
brain | Bos taurus | SUAM-1221 | |
| 3.4.21.26 | 0.0123 | - |
- |
Homo sapiens | Baicalin | |
| 3.4.21.26 | 0.014 | - |
human peripheral blood mononuclear cells | Homo sapiens | benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate | |
| 3.4.21.26 | 0.0571 | - |
brain | Canis lupus familiaris | 1-[[(2S)-1-(4-phenylbutanoyl)pyrrolidin-2-yl]carbonyl]pyrrolidin-2-one | |
| 3.4.21.26 | 0.065 | - |
- |
Homo sapiens | 4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide | |
| 3.4.21.26 | 0.102 | - |
brain | Canis lupus familiaris | 4-phenyl-1-[(4S)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one | |
| 3.4.21.26 | 0.145 | - |
- |
Homo sapiens | Berberine | |
| 3.4.21.26 | 1 | - |
brain, value above | Bos taurus | 4-phenyl-1-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]butan-1-one | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Mus musculus |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Homo sapiens |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Rattus norvegicus |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Bos taurus |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Oryctolagus cuniculus |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Canis lupus familiaris |
| 3.4.21.26 | physiological function | participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases | Sus scrofa |
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Release 2023.1 (January 2023)
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