Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Davies, D.R.; Mamat, B.; Magnusson, O.T.; Christensen, J.; Haraldsson, M.H.; Mishra, R.; Pease, B.; Hansen, E.; Singh, J.; Zembower, D.; Kim, H.; Kiselyov, A.S.; Burgin, A.B.; Gurney, M.E.; Stewart, L.J.
    Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography (2009), J. Med. Chem., 52, 4694-4715.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 (4-fluorophenyl)(pyridin-4-yl)methanone
-
 Homo sapiens
3.3.2.6 (R)-2-[4-(4-thiophene-3-ylbenzoyl)phenoxymethyl]pyrrolidine
-
 Homo sapiens
3.3.2.6 1-(2,2'-bithiophen-5-yl)methanamine
-
 Homo sapiens
3.3.2.6 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid
-
 Homo sapiens
3.3.2.6 1-[4-(thiophen-2-yl)phenyl]methanamine
-
 Homo sapiens
3.3.2.6 1H-indol-5-ol
-
 Homo sapiens
3.3.2.6 3-(benzyloxy)pyridin-2-amine
-
 Homo sapiens
3.3.2.6 4-(2-amino-1,3-thiazol-4-yl)phenol
-
 Homo sapiens
3.3.2.6 4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid i.e. DG-051 Homo sapiens
3.3.2.6 5-(2-pyrrolidin-1-ylethoxy)-1H-indole
-
 Homo sapiens
3.3.2.6 5-chloro-1H-indole
-
 Homo sapiens
3.3.2.6 5-fluoro-1H-indole
-
 Homo sapiens
3.3.2.6 benzyl[4-((R)-1-pyrrolidin-2-ylmethoxy)phenyl]amine
-
 Homo sapiens
3.3.2.6 bestatin
-
 Homo sapiens
3.3.2.6 dihydroresveratrol
-
 Homo sapiens
3.3.2.6 additional information structure-based drug discovery, inhibitor binding and molecular docking, overview Homo sapiens
3.3.2.6 N-methyl-1-[2-(thiophen-2-yl)phenyl]methanamine
-
 Homo sapiens
3.3.2.6 pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol
-
 Homo sapiens
3.3.2.6 resveratrol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens P09960
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 blood
-
 Homo sapiens
-
3.3.2.6 commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.3.2.6 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.6 8
-
 assay at Homo sapiens