EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.53 | (2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid | - |
Rattus norvegicus | |
3.4.22.53 | (2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid | - |
Rattus norvegicus | |
3.4.22.53 | ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate | - |
Rattus norvegicus | |
3.4.22.53 | MDL28170 | selective calpain inhibitor | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.53 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.53 | testis | - |
Rattus norvegicus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.53 | calpain 2 | - |
Rattus norvegicus |
3.4.22.53 | CAPN2 | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.22.53 | 0.00014 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Rattus norvegicus | (2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid | |
3.4.22.53 | 0.00015 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Rattus norvegicus | MDL28170 | |
3.4.22.53 | 0.00024 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Rattus norvegicus | ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate | |
3.4.22.53 | 0.00041 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Rattus norvegicus | (2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.4.22.53 | Rattus norvegicus | a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2 | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.22.53 | malfunction | the blockage of calpain 2 suppresses p38 MAPK phosphorylation | Rattus norvegicus |
3.4.22.53 | physiological function | calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis | Rattus norvegicus |