BRENDA - Enzyme Database

Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes

Lizama, C.; Lagos, C.F.; Lagos-Cabre, R.; Cantuarias, L.; Rivera, F.; Huenchunir, P.; Perez-Acle, T.; Carrion, F.; Moreno, R.D.; J. Cell. Physiol. 221, 296-305 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.22.53
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
-
Rattus norvegicus
3.4.22.53
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
-
Rattus norvegicus
3.4.22.53
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
-
Rattus norvegicus
3.4.22.53
MDL28170
selective calpain inhibitor
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.4.22.53
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.22.53
testis
-
Rattus norvegicus
-
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.22.53
0.00014
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
3.4.22.53
0.00015
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
MDL28170
3.4.22.53
0.00024
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
3.4.22.53
0.00041
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.22.53
0.00014
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
3.4.22.53
0.00015
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
MDL28170
3.4.22.53
0.00024
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
3.4.22.53
0.00041
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
Rattus norvegicus
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.22.53
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
-
Rattus norvegicus
3.4.22.53
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
-
Rattus norvegicus
3.4.22.53
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
-
Rattus norvegicus
3.4.22.53
MDL28170
selective calpain inhibitor
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.22.53
testis
-
Rattus norvegicus
-
Expression
EC Number
Organism
Commentary
Expression
3.4.22.53
Rattus norvegicus
a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2
up
General Information
EC Number
General Information
Commentary
Organism
3.4.22.53
malfunction
the blockage of calpain 2 suppresses p38 MAPK phosphorylation
Rattus norvegicus
3.4.22.53
physiological function
calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.4.22.53
malfunction
the blockage of calpain 2 suppresses p38 MAPK phosphorylation
Rattus norvegicus
3.4.22.53
physiological function
calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis
Rattus norvegicus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
3.4.22.53
Rattus norvegicus
a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2
up