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Literature summary extracted from

  • Cowell, C.F.; Doeppler, H.; Yan, I.K.; Hausser, A.; Umezawa, Y.; Storz, P.
    Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling (2009), J. Cell Sci., 122, 919-928.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 additional information PLD1 is activated by oxidative stress in various cell lines. Reactive oxygen species-induced PLD1 activation involves PKC and tyrosine kinases in various mammalian cell systems Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol
-
 Homo sapiens
3.1.4.4 additional information inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress Homo sapiens
3.1.4.4 propranolol
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 Golgi apparatus
-
 Homo sapiens 5794
-
3.1.4.4 mitochondrion
-
 Homo sapiens 5739
-
3.1.4.4 additional information PLD1 is located at most cellular organelles, including the perinuclear region, mitochondria and the Golgi apparatus Homo sapiens
-
-
3.1.4.4 perinuclear space
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Homo sapiens PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HeLa cell
-
 Homo sapiens
-
3.1.4.4 additional information ubiquitous expression of PLD1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD1 mediates the reactive oxygen species-induced increase in diacylglycerol, which facilitates PKD1 localization to the mitochondria and its activation. Diacylglycerol, to which PKD1 is recruited, is formed downstream of phospholipase D1 and is required for PKD1 localization in the mitochondria and well as activation under oxidative stress, overview. Role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling Homo sapiens ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 phospholipase D1
-
 Homo sapiens
3.1.4.4 PLD1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocks PKD1 activation under oxidative stress Homo sapiens
3.1.4.4 physiological function role for PLD1-induced diacylglycerol as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling, overview Homo sapiens